[HTML][HTML] Rationale of using the dual chemokine receptor CCR2/CCR5 inhibitor cenicriviroc for the treatment of COVID-19

DC Files, F Tacke, A O'Sullivan, P Dorr… - PLoS …, 2022 - journals.plos.org
Coronavirus Disease 2019 (COVID-19), caused by Severe Acute Respiratory Syndrome
Coronavirus 2 (SARS-CoV-2), has created a global pandemic infecting over 230 million …

[HTML][HTML] The chemokine receptor antagonist cenicriviroc inhibits the replication of SARS-CoV-2 in vitro

M Okamoto, M Toyama, M Baba - Antiviral research, 2020 - Elsevier
Cenicriviroc (CVC) is a small-molecule chemokine receptor antagonist with highly potent
and selective anti-human immunodeficiency virus type 1 (HIV-1) activity through …

[HTML][HTML] CCR5 inhibition in critical COVID-19 patients decreases inflammatory cytokines, increases CD8 T-cells, and decreases SARS-CoV2 RNA in plasma by day 14

BK Patterson, H Seethamraju, K Dhody… - International Journal of …, 2021 - Elsevier
Objective Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is
now a global pandemic. Emerging results indicate a dysregulated immune response. Given …

Variant-genetic and transcript-expression analysis showed a role for the chemokine-receptor CCR5 in COVID-19 severity

E Cuesta-Llavona, J Gómez, GM Albaiceta… - International …, 2021 - Elsevier
The chemokine receptor CCR5 has been implicated in COVID-19. CCR5 and its ligands are
overexpressed in patients. The pharmacological targeting of CCR5 would improve the …

Role of CCL2/CCR2 axis in the pathogenesis of COVID-19 and possible Treatments: All options on the Table

M Ranjbar, A Rahimi, Z Baghernejadan… - International …, 2022 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is cause of the novel
coronavirus disease (COVID-19). In the last two years, SARS-CoV-2 has infected millions of …

CCR2 signaling restricts SARS-CoV-2 infection

A Vanderheiden, J Thomas, AL Soung… - MBio, 2021 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a historic
pandemic of respiratory disease (coronavirus disease 2019 [COVID-19]), and current …

Disruption of the CCL5/RANTES-CCR5 pathway restores immune homeostasis and reduces plasma viral load in critical COVID-19

BK Patterson, H Seethamraju, K Dhody, MJ Corley… - MedRxiv, 2020 - medrxiv.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of
coronavirus disease 2019 (COVID-19), is now pandemic with nearly three million cases …

[HTML][HTML] Chemokine-based therapeutics for the treatment of inflammatory and fibrotic convergent pathways in COVID-19

DR Julian, MA Kazakoff, A Patel, J Jaynes… - Current pathobiology …, 2021 - Springer
Abstract Coronavirus disease 2019 (COVID-19) is an infectious disease caused by the
SARS-CoV-2 betacoronavirus and has taken over 761,426 American lives as of the date of …

[HTML][HTML] Cytokines and chemokines in SARS-CoV-2 infections—therapeutic strategies targeting cytokine storm

A Pum, M Ennemoser, T Adage, AJ Kungl - Biomolecules, 2021 - mdpi.com
The recently identified severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
virus, the cause of coronavirus disease (COVID-19) and the associated ongoing pandemic …

[HTML][HTML] Blocking inflammation on the way: Rationale for CXCR2 antagonists for the treatment of COVID-19

LM Koenig, DFR Boehmer, P Metzger… - Journal of Experimental …, 2020 - rupress.org
An exacerbated and unbalanced immune response may account for the severity of COVID-
19, the disease caused by the novel severe acute respiratory syndrome (SARS) coronavirus …