[PDF][PDF] Genome-wide risk prediction of common diseases across ancestries in one million people
Polygenic risk scores (PRS) measure genetic disease susceptibility by combining risk effects
across the genome. For coronary artery disease (CAD), type 2 diabetes (T2D), and breast …
across the genome. For coronary artery disease (CAD), type 2 diabetes (T2D), and breast …
[PDF][PDF] Incorporating family history of disease improves polygenic risk scores in diverse populations
Polygenic risk scores (PRSs) derived from genotype data and family history (FH) of disease
provide valuable information for predicting disease risk, but PRSs perform poorly when …
provide valuable information for predicting disease risk, but PRSs perform poorly when …
[PDF][PDF] Inclusion of variants discovered from diverse populations improves polygenic risk score transferability
TB Cavazos, JS Witte - Human Genetics and Genomics Advances, 2021 - cell.com
The majority of polygenic risk scores (PRSs) have been developed and optimized in
individuals of European ancestry and may have limited generalizability across other …
individuals of European ancestry and may have limited generalizability across other …
[HTML][HTML] On cross-ancestry cancer polygenic risk scores
Polygenic risk scores (PRS) can provide useful information for personalized risk stratification
and disease risk assessment, especially when combined with non-genetic risk factors …
and disease risk assessment, especially when combined with non-genetic risk factors …
Principles and methods for transferring polygenic risk scores across global populations
Polygenic risk scores (PRSs) summarize the genetic predisposition of a complex human trait
or disease and may become a valuable tool for advancing precision medicine. However …
or disease and may become a valuable tool for advancing precision medicine. However …
Polygenic scores for height in admixed populations
BD Bitarello, I Mathieson - G3: Genes, Genomes, Genetics, 2020 - academic.oup.com
Polygenic risk scores (PRS) use the results of genome-wide association studies (GWAS) to
predict quantitative phenotypes or disease risk at an individual level, and provide a potential …
predict quantitative phenotypes or disease risk at an individual level, and provide a potential …
[HTML][HTML] Quantifying portable genetic effects and improving cross-ancestry genetic prediction with GWAS summary statistics
Polygenic risk scores (PRS) calculated from genome-wide association studies (GWAS) of
Europeans are known to have substantially reduced predictive accuracy in non-European …
Europeans are known to have substantially reduced predictive accuracy in non-European …
[PDF][PDF] The construction of cross-population polygenic risk scores using transfer learning
As most existing genome-wide association studies (GWASs) were conducted in European-
ancestry cohorts, and as the existing polygenic risk score (PRS) models have limited …
ancestry cohorts, and as the existing polygenic risk score (PRS) models have limited …
A new method for multiancestry polygenic prediction improves performance across diverse populations
Polygenic risk scores (PRSs) increasingly predict complex traits; however, suboptimal
performance in non-European populations raise concerns about clinical applications and …
performance in non-European populations raise concerns about clinical applications and …
[HTML][HTML] Polygenic transcriptome risk scores (PTRS) can improve portability of polygenic risk scores across ancestries
Background Polygenic risk scores (PRS) are valuable to translate the results of genome-
wide association studies (GWAS) into clinical practice. To date, most GWAS have been …
wide association studies (GWAS) into clinical practice. To date, most GWAS have been …