Identification of key factors conquering developmental arrest of somatic cell cloned embryos by combining embryo biopsy and single-cell sequencing
W Liu, X Liu, C Wang, Y Gao, R Gao, X Kou, Y Zhao… - Cell discovery, 2016 - nature.com
Differentiated somatic cells can be reprogrammed into totipotent embryos through somatic
cell nuclear transfer. However, most cloned embryos arrest at early stages and the …
cell nuclear transfer. However, most cloned embryos arrest at early stages and the …
[HTML][HTML] Embryonic development following somatic cell nuclear transfer impeded by persisting histone methylation
Mammalian oocytes can reprogram somatic cells into a totipotent state enabling animal
cloning through somatic cell nuclear transfer (SCNT). However, the majority of SCNT …
cloning through somatic cell nuclear transfer (SCNT). However, the majority of SCNT …
Inhibition of aberrant DNA re-methylation improves post-implantation development of somatic cell nuclear transfer embryos
Somatic cell nuclear transfer (SCNT) enables cloning of differentiated cells by
reprogramming their nuclei to a totipotent state. However, successful full-term development …
reprogramming their nuclei to a totipotent state. However, successful full-term development …
Dux-mediated corrections of aberrant H3K9ac during 2-cell genome activation optimize efficiency of somatic cell nuclear transfer
Differentiated somatic cells can be reprogrammed to totipotent embryos through somatic cell
nuclear transfer (SCNT) with low efficiency. The histone deacetylase inhibitor trichostatin A …
nuclear transfer (SCNT) with low efficiency. The histone deacetylase inhibitor trichostatin A …
[HTML][HTML] Tough beginnings: alterations in the transcriptome of cloned embryos during the first two cell cycles
R Vassena, Z Han, S Gao, DA Baldwin, RM Schultz… - Developmental …, 2007 - Elsevier
Cloned embryos produced by somatic cell nuclear transfer (SCNT) display a plethora of
phenotypic characteristics that make them different from fertilized embryos, indicating …
phenotypic characteristics that make them different from fertilized embryos, indicating …
Strategies to improve the efficiency of somatic cell nuclear transfer
Mammalian oocytes can reprogram differentiated somatic cells into a totipotent state through
somatic cell nuclear transfer (SCNT), which is known as cloning. Although many mammalian …
somatic cell nuclear transfer (SCNT), which is known as cloning. Although many mammalian …
Equivalency of nuclear transfer‐derived embryonic stem cells to those derived from fertilized mouse blastocysts
S Wakayama, ML Jakt, M Suzuki, R Araki, T Hikichi… - Stem …, 2006 - academic.oup.com
Therapeutic cloning, whereby nuclear transfer (NT) is used to generate embryonic stem cells
(ESCs) from blastocysts, has been demonstrated successfully in mice and cattle. However, if …
(ESCs) from blastocysts, has been demonstrated successfully in mice and cattle. However, if …
Histone demethylase expression enhances human somatic cell nuclear transfer efficiency and promotes derivation of pluripotent stem cells
The extremely low efficiency of human embryonic stem cell (hESC) derivation using somatic
cell nuclear transfer (SCNT) limits its potential application. Blastocyst formation from human …
cell nuclear transfer (SCNT) limits its potential application. Blastocyst formation from human …
Establishment of male and female nuclear transfer embryonic stem cell lines from different mouse strains and tissues
S Wakayama, H Ohta, S Kishigami… - Biology of …, 2005 - academic.oup.com
Nuclear transfer can be used to generate embryonic stem cell lines from somatic cells, and
these have great potential in regenerative medicine. However, it is still unclear whether any …
these have great potential in regenerative medicine. However, it is still unclear whether any …
The cytoplasm of mouse germinal vesicle stage oocytes can enhance somatic cell nuclear reprogramming
In mammalian cloning, evidence suggests that genomic reprogramming factors are located
in the nucleus rather than the cytoplasm of oocytes or zygotes. However, little is known …
in the nucleus rather than the cytoplasm of oocytes or zygotes. However, little is known …