Gut microbiome, big data and machine learning to promote precision medicine for cancer

G Cammarota, G Ianiro, A Ahern, C Carbone… - Nature reviews …, 2020 - nature.com
The gut microbiome has been implicated in cancer in several ways, as specific microbial
signatures are known to promote cancer development and influence safety, tolerability and …

[HTML][HTML] Microbiome in cancer: Role in carcinogenesis and impact in therapeutic strategies

MM Rahman, MR Islam, S Shohag, MT Ahasan… - Biomedicine & …, 2022 - Elsevier
Cancer is the world's second-leading cause of death, and the involvement of microbes in a
range of diseases, including cancer, is well established. The gut microbiota is known to play …

Cancer pharmacomicrobiomics: targeting microbiota to optimise cancer therapy outcomes

NLN Ting, HCH Lau, J Yu - Gut, 2022 - gut.bmj.com
Despite the promising advances in novel cancer therapy such as immune checkpoint
inhibitors (ICIs), limitations including therapeutic resistance and toxicity remain. In recent …

Gut microbiome in colorectal cancer: Clinical diagnosis and treatment

Y Liu, HCH Lau, WY Cheng, J Yu - Genomics, Proteomics & …, 2023 - academic.oup.com
Colorectal cancer (CRC) is one of the most frequently diagnosed cancers and the leading
cause of cancer-associated deaths. Epidemiological studies have shown that both genetic …

[HTML][HTML] Role of the microbiome in non-gastrointestinal cancers

M Pevsner-Fischer, T Tuganbaev, M Meijer… - World journal of …, 2016 - ncbi.nlm.nih.gov
Abstract “The forgotten organ”, the human microbiome, comprises a community of
microorganisms that colonizes various sites of the human body. Through coevolution of …

[HTML][HTML] Clinical applications of gut microbiota in cancer biology

SH Wong, TNY Kwong, CY Wu, J Yu - Seminars in cancer biology, 2019 - Elsevier
The involvement of microorganisms in cancer has been increasing recognized. Collectively,
microorganisms have been estimated to account for∼ 20% of all cancers worldwide. Recent …

Harness the functions of gut microbiome in tumorigenesis for cancer treatment

MH Lee - Cancer Communications, 2021 - Wiley Online Library
It has been shown that gut microbiota dysbiosis leads to physiological changes and links to
a number of diseases, including cancers. Thus, many cancer categories and treatment …

[HTML][HTML] Microbiome and colorectal cancer: Roles in carcinogenesis and clinical potential

E Saus, S Iraola-Guzmán, JR Willis… - Molecular aspects of …, 2019 - Elsevier
The gastrointestinal tract harbors most of the microbiota associated with humans. In recent
years, there has been a surge of interest in assessing the relationships between the gut …

Targeting the gut and tumor microbiota in cancer

EM Park, M Chelvanambi, N Bhutiani, G Kroemer… - Nature medicine, 2022 - nature.com
Microorganisms within the gut and other niches may contribute to carcinogenesis, as well as
shaping cancer immunosurveillance and response to immunotherapy. Our understanding of …

Harnessing machine learning for development of microbiome therapeutics

LE McCoubrey, M Elbadawi, M Orlu, S Gaisford… - Gut …, 2021 - Taylor & Francis
The last twenty years of seminal microbiome research has uncovered microbiota's intrinsic
relationship with human health. Studies elucidating the relationship between an unbalanced …