[HTML][HTML] Designed mosaic nanoparticles enhance cross-reactive immune responses in mice
Using computational methods, we designed 60-mer nanoparticles displaying SARS-like
betacoronavirus (sarbecovirus) receptor-binding domains (RBDs) by (i) creating RBD …
betacoronavirus (sarbecovirus) receptor-binding domains (RBDs) by (i) creating RBD …
[HTML][HTML] Mosaic RBD nanoparticles protect against multiple sarbecovirus challenges in animal models
To combat future SARS-CoV-2 variants and spillovers of SARS-like betacoronaviruses
(sarbecoviruses) threatening global health, we designed mosaic nanoparticles presenting …
(sarbecoviruses) threatening global health, we designed mosaic nanoparticles presenting …
[HTML][HTML] Mosaic sarbecovirus nanoparticles elicit cross-reactive responses in pre-vaccinated animals
AA Cohen, JR Keeffe, A Schiepers, SE Dross… - bioRxiv, 2024 - ncbi.nlm.nih.gov
SUMMARY Immunization with mosaic-8b [60-mer nanoparticles presenting 8 SARS-like
betacoronavirus (sarbecovirus) receptor-binding domains (RBDs)] elicits more broadly cross …
betacoronavirus (sarbecovirus) receptor-binding domains (RBDs)] elicits more broadly cross …
Mosaic RBD nanoparticles protect against challenge by diverse sarbecoviruses in animal models
To combat future severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants
and spillovers of SARS-like betacoronaviruses (sarbecoviruses) threatening global health …
and spillovers of SARS-like betacoronaviruses (sarbecoviruses) threatening global health …
Mosaic sarbecovirus vaccination elicits cross-reactive responses in pre-immunized animals.
AA Cohen, JR Keeffe, A Schiepers… - Biorxiv: the Preprint …, 2024 - europepmc.org
SUMMARY Immunization with mosaic-8b [60-mer nanoparticles presenting 8 SARS-like
betacoronavirus (sarbecovirus) receptor-binding domains (RBDs)] elicits more broadly cross …
betacoronavirus (sarbecovirus) receptor-binding domains (RBDs)] elicits more broadly cross …
Super-immunity by broadly protective nanobodies to sarbecoviruses
Vaccine boosters and infection can facilitate the development of SARS-CoV-2 antibodies
with improved potency and breadth. Here, we observed super-immunity in a camelid …
with improved potency and breadth. Here, we observed super-immunity in a camelid …
Elicitation of broadly protective sarbecovirus immunity by receptor-binding domain nanoparticle vaccines
Understanding vaccine-elicited protection against SARS-CoV-2 variants and other
sarbecoviruses is key for guiding public health policies. We show that a clinical stage …
sarbecoviruses is key for guiding public health policies. We show that a clinical stage …
Mosaic RBD nanoparticle elicits immunodominant antibody responses across sarbecoviruses
C Liu, S Xu, Y Zheng, Y Xie, K Xu, Y Chai, T Luo, L Dai… - Cell Reports, 2024 - cell.com
Nanoparticle vaccines displaying mosaic receptor-binding domains (RBDs) or spike (S) from
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or other sarbecoviruses are …
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or other sarbecoviruses are …
Neutralizing monoclonal antibodies elicited by mosaic RBD nanoparticles bind conserved sarbecovirus epitopes
Increased immune evasion by SARS-CoV-2 variants of concern highlights the need for new
therapeutic neutralizing antibodies. Immunization with nanoparticles co-displaying spike …
therapeutic neutralizing antibodies. Immunization with nanoparticles co-displaying spike …
Stabilization of the SARS-CoV-2 spike receptor-binding domain using deep mutational scanning and structure-based design
The unprecedented global demand for SARS-CoV-2 vaccines has demonstrated the need
for highly effective vaccine candidates that are thermostable and amenable to large-scale …
for highly effective vaccine candidates that are thermostable and amenable to large-scale …