Bone defects and infections pose significant challenges for treatment, requiring a
comprehensive approach for prevention and treatment. Thus, this study sought to evaluate …

Background: Antibiotics delivered from implanted bone substitute materials (BSM) can
potentially be used to prevent acute infections and biofilm formation, providing high …

Osteomyelitis remains a significant complication in orthopedic surgeries. Although infection
rates remain steady at 1-3% for primary orthopedic surgeries, overall numbers of orthopedic …

The use of polymethylmetacrylate beads for local delivery of antibiotics requires a second
surgical procedure for their removal and resorbable calcium sulphate exhibits cytotoxic …

Introduction There is paucity of literature about antibiotic uptake in bone grafts soaked in
antibiotic solutions at room temperature in the operation theatre. We hypothesized that if …

Infected bone defects and osteomyelitis are encountered frequently in trauma cases.
Currently, the standard of care for osteomyelitis cases is prolonged systemic antibiotic …

Antibiotic loading of bone regenerative materials is a promising way to protect augmentation
procedures from infection during the resorption phase of bone substitutes. Especially in the …

A method of care for these infected nonunions is prolonged intravenous systemic antibiotic
treatment and implantation of methyl methacrylate antibiotic carrier beads to delivery high …

The use of bone allografts is contraindicated in septic revision surgery due to the high risk of
graft reinfection. Antibiotic release from the graft may solve the problem and these …

In this study HERAFILL® granules containing gentamicin was evaluated as a bone void
filling material once mixed with allograft bone grafts. The efficacy of the bone grafts mixed …