The type-I interferon (IFN) response constitutes the major innate immune pathway against
viruses in mammals. Despite its critical importance for antiviral defence, this pathway is …

There is a mystery unfolding, the solution of which has implications for the understanding of
both stem cell biology and the evolution of the vertebrate pathogen defense response. At the …

Upon virus infection, pluripotent stem cells neither induce nor respond to canonical type I
interferons (IFN-I). To better understand this biology, we characterized induced pluripotent …

Embryonic stem cells (ESCs) have received tremendous attention because of their potential
applications in regenerative medicine. Over the past two decades, intensive research has …

Type I interferon (IFN-α/β) binds to cell surface receptors IFNAR1 and IFNAR2 and triggers a
signaling cascade that leads to the transcription of hundreds of IFN-stimulated genes. This …

Embryonic stem cells (ESCs) represent a promising cell source for regenerative medicine.
Intensive research over the past 2 decades has led to the feasibility of using ESC …

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Stem cells intrinsically express a subset of genes which are normally associated with
interferon stimulation and the innate immune response. However, the expression of these …

The innate immunity of embryonic stem cells (ESCs) has recently emerged as an important
issue in ESC biology and in ESC-based regenerative medicine. We have recently reported …

Embryonic stem cells (ESCs) are considered to be a promising cell source for regenerative
medicine because of their unlimited capacity for self-renewal and differentiation. However …