Clinical immunologists, among other problems, routinely face a question: what is the best
time and dose for a certain therapeutic agent to be administered to the patient in order to …

An optimal control problem for cancer chemotherapy is considered that includes
immunological activity. In the objective a weighted average of several quantities that …

We investigate a mathematical model of tumor–immune interactions with chemotherapy, and
strategies for optimally administering treatment. In this paper we analyze the dynamics of …

We investigate mathematical models for the dynamics between tumor cells, immune-effector
cells, and cytokine interleukin-2 (IL-2). To better determine under what circumstances the …

Understanding the dynamics of human hosts and tumors is of critical importance. A
mathematical model was developed that explored the immune response to tumors that was …

Cancer immunotherapy aims at eliciting an immune system response against the tumor.
However, it is often characterized by toxic side-effects. Limiting the tumor growth and …

We present an optimal control strategy for nonlinear systems with application to the drug
therapy of cancer. The tumour growth model is represented by a system of equations from …

We investigate a mathematical model for the dynamics between tumor cells, immune-
effector cells, and the cytokine interleukin-2 (IL-2). In order to better determine under what …

We investigate a mathematical population model of tumor-immune interactions. The
populations involved are tumor cells, specific and non-specific immune cells, and …

Cancer is a highly complex disease with a myriad of different manifestations. The reasons
for this simply lie not only in the many types of different cells that exist in our bodies, but also …