[HTML][HTML] Single-nucleus transcriptomic profiling of multiple organs in a rhesus macaque model of SARS-CoV-2 infection

Q Ma, W Ma, TZ Song, Z Wu, Z Liu, Z Hu… - Zoological …, 2022 - ncbi.nlm.nih.gov
Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes
diverse clinical manifestations and tissue injuries in multiple organs. However, cellular and …

Differential transcriptomic landscapes of multiple organs from SARS-CoV-2 early infected rhesus macaques

CC Gao, M Li, W Deng, CH Ma, YS Chen, YQ Sun… - Protein & …, 2022 - academic.oup.com
SARS-CoV-2 infection causes complicated clinical manifestations with variable multi-organ
injuries, however, the underlying mechanism, in particular immune responses in different …

Spatial transcriptome atlas reveals pulmonary microstructure-specific COVID-19 gene signatures in cynomolgus macaques

T Oh, G Kim, SH Baek, YM Woo, BS Koo… - Communications …, 2023 - nature.com
Characterizing the host response to severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) at the molecular level is necessary to understand viral pathogenesis and …

Single-nuclei characterization of pervasive transcriptional signatures across organs in response to COVID-19

AA Granados, S Bucher, H Song, A Agrawal, AT Chen… - Elife, 2023 - elifesciences.org
Background: Infection by coronavirus SARS-CoV2 is a severe and often deadly disease that
has implications for the respiratory system and multiple organs across the human body …

Single-cell RNA sequencing reveals SARS-CoV-2 infection dynamics in lungs of African green monkeys

E Speranza, BN Williamson, F Feldmann… - Science translational …, 2021 - science.org
Detailed knowledge about the dynamics of severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) infection is important for uncovering the viral and host factors that contribute …

[HTML][HTML] A single-cell and spatial atlas of autopsy tissues reveals pathology and cellular targets of SARS-CoV-2

TM Delorey, CGK Ziegler, G Heimberg, R Normand… - Biorxiv, 2021 - ncbi.nlm.nih.gov
The SARS-CoV-2 pandemic has caused over 1 million deaths globally, mostly due to acute
lung injury and acute respiratory distress syndrome, or direct complications resulting in …

Similarities and differences in the acute-phase response to SARS-CoV-2 in rhesus macaques and African green monkeys

C Coleman, LA Doyle-Meyers… - Frontiers in …, 2021 - frontiersin.org
Understanding SARS-CoV-2 immune pathology is critical for the development of effective
vaccines and treatments. Here, we employed unbiased serial whole-blood transcriptome …

Transcriptomic profiling of cardiac tissues from SARS‐CoV‐2 patients identifies DNA damage

A Kulasinghe, N Liu, CW Tan, J Monkman… - …, 2023 - Wiley Online Library
The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is known to present
with pulmonary and extra‐pulmonary organ complications. In comparison with the 2009 …

Systemic tissue and cellular disruption from SARS-CoV-2 infection revealed in COVID-19 autopsies and spatial omics tissue maps

J Park, J Foox, T Hether, D Danko, S Warren, Y Kim… - bioRxiv, 2021 - biorxiv.org
Abstract The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) virus has
infected over 115 million people and caused over 2.5 million deaths worldwide. Yet, the …

Spatial mapping of SARS-CoV-2 and H1N1 lung injury identifies differential transcriptional signatures

C Margaroli, P Benson, NS Sharma, MC Madison… - Cell Reports …, 2021 - cell.com
Severe SARS-CoV-2 infection often leads to the development of acute respiratory distress
syndrome (ARDS), with profound pulmonary patho-histological changes post-mortem. It is …