Pathological changes within the cerebral vasculature in Alzheimer's disease: New perspectives

RA Fisher, JS Miners, S Love - Brain Pathology, 2022 - Wiley Online Library
Cerebrovascular disease underpins vascular dementia (VaD), but structural and functional
changes to the cerebral vasculature contribute to disease pathology and cognitive decline in …

Neurovascular mechanisms and blood–brain barrier disorder in Alzheimer's disease

RD Bell, BV Zlokovic - Acta neuropathologica, 2009 - Springer
Vascular dysfunction has a critical role in Alzheimer's disease (AD). Recent data from brain
imaging studies in humans and animal models suggest that cerebrovascular dysfunction …

Neurovascular dysfunction and faulty amyloid β-peptide clearance in Alzheimer disease

AP Sagare, RD Bell… - Cold Spring …, 2012 - perspectivesinmedicine.cshlp.org
Neurovascular dysfunction is an integral part of Alzheimer disease (AD). Changes in the
brain vascular system may contribute in a significant way to the onset and progression of …

Neurovascular defects and faulty amyloid-β vascular clearance in Alzheimer's disease

AP Sagare, RD Bell, BV Zlokovic - Journal of Alzheimer's …, 2013 - content.iospress.com
The evidence that neurovascular dysfunction is an integral part of Alzheimer's disease (AD)
pathogenesis has continued to emerge in the last decade. Changes in the brain vasculature …

Neurovascular Pathways and Alzheimer Amyloid β‐peptide

BV Zlokovic, R Deane, J Sallstrom, N Chow… - Brain …, 2005 - Wiley Online Library
According to the prevailing amyloid cascade hypothesis, the onset and progression of a
chronic neurodegenerative condition in Alzheimer disease (AD) is initiated by the amyloid β …

Vascular contributions to Alzheimer's disease

LB Eisenmenger, A Peret, BM Famakin, A Spahic… - Translational …, 2023 - Elsevier
Alzheimer's disease (AD) is the most common cause of dementia and is characterized by
progressive neurodegeneration and cognitive decline. Understanding the pathophysiology …

Vascular disorder in Alzheimer's disease: role in pathogenesis of dementia and therapeutic targets

BV Zlokovic - Advanced drug delivery reviews, 2002 - Elsevier
It is not clear whether Alzheimer's Disease (AD) is primarily a neurodegenerative disorder or
not. A body of evidence suggests that vascular disorder in brains of individuals with AD …

Cerebral amyloid angiopathy and Alzheimer disease—one peptide, two pathways

SM Greenberg, BJ Bacskai… - Nature Reviews …, 2020 - nature.com
The shared role of amyloid-β (Aβ) deposition in cerebral amyloid angiopathy (CAA) and
Alzheimer disease (AD) is arguably the clearest instance of crosstalk between …

Adjusting the compass: new insights into the role of angiogenesis in Alzheimer's disease

WA Jefferies, KA Price, KE Biron, F Fenninger… - Alzheimer's research & …, 2013 - Springer
Growing evidence suggests that vascular perturbation plays a critical role in the
pathogenesis of Alzheimer's disease (AD). It appears to be a common feature in addition to …

Neurovascular mechanisms of Alzheimer's neurodegeneration

BV Zlokovic - Trends in neurosciences, 2005 - cell.com
In contrast to traditional neuroncentric views of Alzheimer's disease (AD), recent findings
indicate that neurovascular dysfunction contributes to cognitive decline and …