Killer cell immunoglobulin-like receptor variants are associated with protection from symptoms associated with more severe course in Parkinson disease

KM Anderson, DG Augusto, R Dandekar… - The Journal of …, 2020 - journals.aai.org
Immune dysfunction plays a role in the development of Parkinson disease (PD). NK cells
regulate immune functions and are modulated by killer cell immunoglobulin-like receptors …

[HTML][HTML] Distinctive CD56dim NK subset profiles and increased NKG2D expression in blood NK cells of Parkinson's disease patients

S Weber, KB Menees, J Park, J Agin-Liebes… - npj Parkinson's …, 2024 - nature.com
Mounting data suggest an important role for the immune system in Parkinson's disease (PD).
Previous evidence of increased natural killer (NK) cell populations in PD suggests a …

KIRs and their HLA ligands in remitting–relapsing multiple sclerosis

C Fusco, FR Guerini, G Nocera, G Ventrella… - Journal of …, 2010 - Elsevier
Killer Immunoglobulin-like Receptor (KIR) genes may affect both resistance and
susceptibility to autoimmune disorders, but their role in the pathogenesis of Multiple …

Killer cell immunoglobulin-like receptor genes in Spanish multiple sclerosis patients

JA García-León, MJ Pinto-Medel, L García-Trujillo… - Molecular …, 2011 - Elsevier
Killer cell immunoglobulin-like receptors (KIRs) are regulators of cytolytic activity of natural
killer and certain T cells through interactions with human leukocyte antigen (HLA) class I …

The role of KIR2DS1 in multiple sclerosis-KIR in Portuguese MS patients

A Bettencourt, AM Silva, C Carvalho, B Leal… - Journal of …, 2014 - Elsevier
Abstract Killer Immunoglobulin-like Receptor (KIR) genes may influence both resistance and
susceptibility to different autoimmune diseases, but their role in the pathogenesis of Multiple …

[HTML][HTML] Multiple sclerosis is accompanied by lack of KIR2DS1 gene: A meta-analysis

F Shahsavar, S Mapar, SAY Ahmadi - Genomics data, 2016 - Elsevier
Multiple sclerosis (MS) is a disease in which we can recognize destruction of the myelin that
is around nerve cells of brain and spinal cord called as oligodendrocytes. Both genetic and …

Killer immunoglobulin-like receptor locus polymorphisms in multiple sclerosis

I Jelčić, KC Hsu, K Kakalacheva… - Multiple Sclerosis …, 2012 - journals.sagepub.com
Objective: The objective of this study was to analyze whether inhibitory and activating killer
cell immunoglobulin-like receptors (KIRs) and human leukocyte antigen (HLA) class I alleles …

Molecular determinant-based typing of KIR alleles and KIR ligands

R Bari, M Leung, VE Turner, C Embrey, B Rooney… - Clinical …, 2011 - Elsevier
Killer cell immunoglobulin-like receptors (KIRs) regulate NK cell function. KIRs and their
HLA ligands are highly polymorphic in nature with substantial allelic polymorphism. At …

[HTML][HTML] Human diversity of killer cell immunoglobulin-like receptors and disease

R Rajalingam - The Korean journal of hematology, 2011 - synapse.koreamed.org
Natural Killer (NK) cells are the third population of lymphocyte in the mononuclear cell
compartment that triggers first-line of defense against viral infection and tumor …

[HTML][HTML] Natural killer cells have an activated profile in early Parkinson's disease

J Holbrook, B Patel, M Camacho, L Kahanawita… - Journal of …, 2023 - Elsevier
Immune dysregulation is heavily implicated in Parkinson's disease (PD) but the role of
Natural Killer (NK) cells has not been well characterised. Accumulating evidence indicates …