The androgen receptor (AR) is a member of the ligand-activated nuclear receptor family of
transcription factors. AR's transactivation activity is turned on by the binding of androgens …

The androgen receptor (AR) is a ligand-inducible transcription factor, a member of the
nuclear receptor superfamily, which plays an important role in the development and …

Androgens play a key role in the development and progression of prostate cancer, and
androgen deprivation therapy (ADT) is the first line treatment for advanced disease …

Prostate cancer (PCa) progression relies on androgen receptor (AR) action. Preventing AR's
ligand-activation is the frontline treatment for metastatic PCa. Androgen deprivation therapy …

Androgen receptor (AR) is a validated drug target for prostate cancer based on its role in
proliferation, survival, and metastases of prostate cancer cells. Unfortunately, despite recent …

The androgen receptor (AR) plays an essential role in the growth and progression of
prostate cancer (CaP). Ligand-activated AR inside the nucleus binds to the androgen …

The transformation of prostate cancer from an androgen-dependent state to an androgen‑
independent state is a lethal progression. Alterations in transcriptional programs are the …

The androgen receptor (AR) is a nuclear receptor that governs gene expression programs
required for prostate development and male phenotype maintenance. Advanced prostate …

Prostate cancer (PCa) constitutes a significant cause of mortality, with over 37,000 new
deaths each year. It is also the most commonly diagnosed cancer in older men, with more …

The aberrant expression of androgen receptor (AR)-dependent transcriptional programs is a
defining pathology of the development and progression of prostate cancers. Transcriptional …