Neuroprotective properties of peroxisome proliferator-activated receptor alpha (PPARα) and its lipid ligands

M Fidaleo, F Fanelli, M Paola Ceru… - Current medicinal …, 2014 - ingentaconnect.com
Signalling lipids are known to control a wide array of cellular processes, including cell
proliferation, apoptosis, migration, and energy metabolism. Fatty acids and their derivatives …

Recent Insights on the Role of PPAR-β/δ in Neuroinflammation and Neurodegeneration, and Its Potential Target for Therapy

AK Strosznajder, S Wójtowicz, MJ Jeżyna… - Neuromolecular …, 2021 - Springer
Peroxisome proliferator-activated receptor (PPAR) β/δ belongs to the family of hormone and
lipid-activated nuclear receptors, which are involved in metabolism of long-chain fatty acids …

[HTML][HTML] Peroxisome proliferator-activated receptor β/δ in the brain: facts and hypothesis

MG Hall, L Quignodon, B Desvergne - PPAR research, 2008 - ncbi.nlm.nih.gov
Abstract peroxisome proliferator-activated receptors (PPARs) are nuclear receptors acting
as lipid sensors. Besides its metabolic activity in peripheral organs, the PPAR beta/delta …

PPAR: a new pharmacological target for neuroprotection in stroke and neurodegenerative diseases

R Bordet, T Ouk, O Petrault, P Gele… - Biochemical Society …, 2006 - portlandpress.com
PPARs (peroxisome-proliferator-activated receptors) are ligand-activated transcriptional
factor receptors belonging to the so-called nuclear receptor family. The three isoforms of …

Peroxisome proliferator-activated receptor (PPAR) β/δ, a possible nexus of PPARα-and PPARγ-dependent molecular pathways in neurodegenerative diseases …

S Aleshin, M Strokin, M Sergeeva, G Reiser - Neurochemistry international, 2013 - Elsevier
Peroxisome proliferator-activated receptors (PPARα,-β/δ and-γ) are lipid-activated
transcription factors. Synthetic PPARα and PPARγ ligands have neuroprotective properties …

PPARs in the central nervous system: roles in neurodegeneration and neuroinflammation

JM Zolezzi, MJ Santos, S Bastías‐Candia… - Biological …, 2017 - Wiley Online Library
Over 25 years have passed since peroxisome proliferators‐activated receptors (PPARs),
were first described. Like other members of the nuclear receptors superfamily, PPARs have …

Role of the peroxisome proliferator-activated receptors (PPAR)-α, β/δ and γ triad in regulation of reactive oxygen species signaling in brain

S Aleshin, G Reiser - Biological chemistry, 2013 - degruyter.com
Overwhelming evidence shows that oxidative stress is a major cause in development of
brain disorders. Low activity of the reactive oxygen species (ROS)-degrading system as well …

Peroxisome proliferator-activated receptors (PPARs): nuclear receptors at the crossroads between lipid metabolism and inflammation

G Chinetti, JC Fruchart, B Staels - Inflammation research, 2000 - Springer
Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription
factors belonging to the nuclear receptor family. PPARs function as regulators of lipid and …

Therapeutic Effects of PPARα on Neuronal Death and Microvascular Impairment

EP Moran, J Ma - PPAR research, 2015 - Wiley Online Library
Peroxisome‐proliferator activated receptor‐alpha (PPARα) is a broadly expressed nuclear
hormone receptor and is a transcription factor for diverse target genes possessing a PPAR …

Neuroprotective Mechanisms of PPARδ: Modulation of Oxidative Stress and Inflammatory Processes

CI Schnegg, ME Robbins - PPAR research, 2011 - Wiley Online Library
Peroxisome proliferator‐activated receptors (PPARα, δ, and γ) are ligand‐activated
transcription factors that regulate a wide range of cellular processes, including inflammation …