Despite the promises made that genomic sequencing would transform therapy by
introducing a new era of personalized medicine, relatively few tangible breakthroughs have …

Systems medicine is an interdisciplinary approach that integrates data from basic research
and clinical practice to improve our understanding and treatment of diseases. Systems …

High‐throughput experimental techniques for generating genomes, transcriptomes,
proteomes, metabolomes, and interactomes have provided unprecedented opportunities to …

Today, in silico studies and trial simulations already complement experimental approaches
in pharmaceutical R&D and have become indispensable tools for decision making and …

Over the past 50 years, like molecular cell biology, medicine and pharmacology have been
driven by a reductionist approach. The focus on individual genes and cellular components …

Background Biomedical research is changing due to the rapid accumulation of experimental
data at an unprecedented scale, revealing increasing degrees of complexity of biological …

Systems biology is an integrative discipline connecting the molecular components within a
single biological scale and also among different scales (eg cells, tissues and organ systems) …

Systems biology is in an exponential development stage in recent years and has been
widely utilized in biomedicine to better understand the molecular basis of human disease …

For life to be understood and disease to become manageable, the wealth of postgenomic
data now needs to be made dynamic. This development requires systems biology …

To achieve the promise of individualized molecular-based medicine, the application of
informatic tools to the entire hierarchy of biological system interactions and dynamics will be …