Current advances in RNA therapeutics for human diseases

H Zogg, R Singh, S Ro - International journal of molecular sciences, 2022 - mdpi.com
Following the discovery of nucleic acids by Friedrich Miescher in 1868, DNA and RNA were
recognized as the genetic code containing the necessary information for proper cell …

RNA therapy: rich history, various applications and unlimited future prospects

YK Kim - Experimental & Molecular Medicine, 2022 - nature.com
RNA therapy refers to the treatment or prevention of diseases using RNA-based molecules.
The recent advent of a series of effective messenger RNA-based vaccines in response to the …

RNA therapeutics in the clinic

A Curreri, D Sankholkar, S Mitragotri… - Bioengineering & …, 2023 - Wiley Online Library
Ribonucleic acid (RNA) therapeutics are being actively researched as a therapeutic
modality in preclinical and clinical studies. They have become one of the most ubiquitously …

Recent advances in RNA therapeutics and RNA delivery systems based on nanoparticles

H Shin, SJ Park, Y Yim, J Kim, C Choi… - Advanced …, 2018 - Wiley Online Library
Recently, there have been significant advances in the field of RNA‐based therapeutics
harnessing exogenous RNAs including small interfering RNA (siRNA), microRNA (miRNA) …

Current RNA-based therapeutics in clinical trials

LY Zhou, Z Qin, YH Zhu, ZY He, T Xu - Current Gene Therapy, 2019 - ingentaconnect.com
Long-term research on various types of RNAs has led to further understanding of diverse
mechanisms, which eventually resulted in the rapid development of RNA-based …

Trials and tribulations of MicroRNA therapeutics

AA Seyhan - International Journal of Molecular Sciences, 2024 - mdpi.com
The discovery of the link between microRNAs (miRNAs) and a myriad of human diseases,
particularly various cancer types, has generated significant interest in exploring their …

MicroRNA therapeutics: discovering novel targets and developing specific therapy

AF Christopher, RP Kaur, G Kaur, A Kaur… - … in clinical research, 2016 - journals.lww.com
MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression
in diverse biological process. They act as intracellular mediators that are necessary for …

[HTML][HTML] RNA therapy: current status and future potential

YK Kim - Chonnam medical journal, 2020 - ncbi.nlm.nih.gov
Recent studies identified diverse RNAs including noncoding RNAs and their various action
mechanisms in the cells. These RNAs regulate a variety of cellular pathways and are …

Next RNA therapeutics: the mine of non-coding

S Garbo, R Maione, M Tripodi, C Battistelli - International journal of …, 2022 - mdpi.com
The growing knowledge on several classes of non-coding RNAs (ncRNAs) and their
different functional roles has aroused great interest in the scientific community. Beyond the …

RNA-based therapeutics: an overview and prospectus

Y Zhu, L Zhu, X Wang, H Jin - Cell death & disease, 2022 - nature.com
The growing understanding of RNA functions and their crucial roles in diseases promotes
the application of various RNAs to selectively function on hitherto “undruggable” proteins …