Genome-scale human protein–protein interaction networks are critical to understanding cell
biology and interpreting genomic data, but challenging to produce experimentally. Through …

Just as reference genome sequences revolutionized human genetics, reference maps of
interactome networks will be critical to fully understand genotype-phenotype relationships …

Background One challenge facing biologists is to tease out useful information from massive
data sets for further analysis. A pathway-based analysis may shed light by projecting …

A catalog of all human protein-protein interactions would provide scientists with a framework
to study protein deregulation in complex diseases such as cancer. Here we demonstrate that …

Background Protein-interaction maps are powerful tools for suggesting the cellular functions
of genes. Although large-scale protein-interaction maps have been generated for several …

We present Interactome INSIDER, a tool to link genomic variant information with structural
protein–protein interactomes. Underlying this tool is the application of machine learning to …

We present the first analysis of the human proteome with regard to interactions between
proteins. We also compare the human interactome with the available interaction datasets …

We describe PROPER-seq (protein-protein interaction sequencing) to map protein-protein
interactions (PPIs) en masse. PROPER-seq first converts transcriptomes of input cells into …

Several attempts have been made to systematically map protein-protein interaction,
or'interactome', networks. However, it remains difficult to assess the quality and coverage of …

Protein-protein interaction maps provide a valuable framework for a better understanding of
the functional organization of the proteome. To detect interacting pairs of human proteins …