Diabetic kidney disease (DKD) is among the most common and serious complications of
both type 1 and type 2 diabetes. In this study, we used KK/Ta‐Ins2Akita (KK‐Akita) mice as a …

Background Hyperglycemia-induced endoplasmic reticulum (ER) stress and oxidative stress
could be causes of renal fibrosis in diabetes. Oleanolic acid (OA) naturally occurs in fruits …

Abstract l‐homoarginine is an endogenous, non‐proteinogenic amino acid that has
emerged as a new player in health and disease. Specifically, low l‐homoarginine levels are …

Diabetic nephropathy (DN) has emerged as the foremost cause of end-stage renal disease
(ESRD) globally. Endoplasmic reticulum (ER) stress plays a critical role in DN progression …

The diabetes mellitus (DM) induces several changes, with substantial increase of reactive
oxygen species (ROS). The ROS cause damage to systemic and renal microvasculature …

Background Diabetic nephropathy (DN) is one of the most serious microvascular
complications of diabetes and the leading cause of end-stage renal failure. However, the …

Methods In this study, animals were fed a folate-deficient diet to mimic human aspartame
metabolism. Eight-week-old ICR mice were divided into control (CTL), 40 mg/kg/day of …

Introduction We previously reported that alpha-lipoic acid (ALA) supplementation protects
against progression of diabetic kidney disease (DKD). In this study, we aim to investigate …

Background: Diabetic nephropathy (DNP) is one of the most serious complications of
diabetes mellitus (DM). In the present study, we investigated the potential of adenosine as a …

Background Diabetic kidney disease (DKD) is among the most important causes for chronic
kidney disease. Anthocyanins (ANT) are polyphenolic compounds present in various food …