[HTML][HTML] Targeting the NLRP3 inflammasome in severe COVID-19

TL Freeman, TH Swartz - Frontiers in immunology, 2020 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a member of the genus
Betacoronavirus within the family Coronaviridae. It is an enveloped single-stranded positive …

The NLRP3 inflammasome and COVID-19: Activation, pathogenesis and therapeutic strategies

N Zhao, B Di, L Xu - Cytokine & growth factor reviews, 2021 - Elsevier
Abstract Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), exhibits a wide spectrum of clinical presentations …

[HTML][HTML] NLRP3 inflammasome activation in COVID-19: an interlink between risk factors and disease severity

S Amin, S Aktar, MM Rahman, MMH Chowdhury - Microbes and infection, 2022 - Elsevier
NLRP3 inflammasome is a critical immune component that plays a crucial role in mounting
innate immune responses. The deleterious effects of inflammasome activation have been …

[HTML][HTML] Severe COVID-19: NLRP3 inflammasome dysregulated

DF Van den Berg, AA Te Velde - Frontiers in immunology, 2020 - frontiersin.org
SARS-CoV-2 might directly activate NLRP3 inflammasome resulting in an endogenous
adjuvant activity necessary to mount a proper adaptive immune response against the virus …

Interleukin-1 and the NLRP3 inflammasome in COVID-19: Pathogenetic and therapeutic implications

N Potere, MG Del Buono, R Caricchio, PC Cremer… - …, 2022 - thelancet.com
A hyperinflammatory response during severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) infection crucially worsens clinical evolution of coronavirus disease 2019 …

[HTML][HTML] Novel coronavirus-induced NLRP3 inflammasome activation: a potential drug target in the treatment of COVID-19

A Shah - Frontiers in immunology, 2020 - frontiersin.org
Novel coronaviruses (nCoVs) encode ion-channel proteins called viroporins such as protein
E, open reading frame 3a (ORF3a) and ORF8a. These viroporins, via mechanisms such as …

Specific inhibition of the NLRP3 inflammasome suppresses immune overactivation and alleviates COVID-19 like pathology in mice

J Zeng, X Xie, XL Feng, L Xu, JB Han, D Yu, QC Zou… - …, 2022 - thelancet.com
Summary Background The Coronavirus Disease 2019 (COVID-19) pandemic has been a
great threat to global public health since 2020. Although the advance on vaccine …

[HTML][HTML] Common NLRP3 inflammasome inhibitors and Covid-19: divide and conquer

GES Batiha, AI Al-Gareeb, D Rotimi, OS Adeyemi… - Scientific African, 2022 - Elsevier
Severe SARS-CoV-2 infection causes systemic inflammation, cytokine storm, and
hypercytokinemia due to activation of the release of pro-inflammatory cytokines that have …

[HTML][HTML] NLRP3 inflammasome activation and SARS-CoV-2-mediated hyperinflammation, cytokine storm and neurological syndromes

D Dutta, J Liu, H Xiong - International journal of physiology …, 2022 - ncbi.nlm.nih.gov
Despite the introduction of vaccines and drugs for SARS-CoV-2, the COVID-19 pandemic
continues to spread throughout the world. In severe COVID-19 patients, elevated levels of …

SARS-CoV-2 N protein promotes NLRP3 inflammasome activation to induce hyperinflammation

P Pan, M Shen, Z Yu, W Ge, K Chen, M Tian… - Nature …, 2021 - nature.com
Excessive inflammatory responses induced upon SARS-CoV-2 infection are associated with
severe symptoms of COVID-19. Inflammasomes activated in response to SARS-CoV-2 …