Background: Measures to quantify changes in the pace of biological aging in response to
intervention are needed to evaluate geroprotective interventions for humans. Previously, we …

Methods to quantify biological aging are emerging as new measurement tools for
epidemiology and population science and have been proposed as surrogate measures for …

Biological aging is the gradual, progressive decline in system integrity that occurs with
advancing chronological age, causing morbidity and disability. Measurements of the pace of …

It was unknown whether plasma protein levels can be estimated based on DNA methylation
(DNAm) levels, and if so, how the resulting surrogates can be consolidated into a powerful …

Biological age is not always concordant with chronological age and the departures are of
interest for understanding how diseases and environmental insults affect tissue function …

Background DNA methylation (DNAm) may play a role in age-related outcomes. It is not yet
known which DNAm-based biomarkers of age acceleration (BoAA) has the strongest …

Background Advanced age is associated with cognitive and physical decline and is a major
risk factor for a multitude of disorders. There is also a gap in life expectancy between males …

Background DNA methylation (DNAm) age acceleration (AgeAccel) has been shown to be
predictive of all-cause mortality but it is unclear what functional aspect (s) of aging it …

Background Age-associated DNA methylation changes provide a promising biomarker for
the aging process. While genome-wide DNA methylation profiles enable robust age …

Importance Accelerated biological aging is associated with decreased physical capability
and cognitive functioning, which are associated with increased risk of morbidity and …