Choosing an appropriate treatment for chronic pain remains problematic, and despite the
available medication for its treatment, still, many patients complain about pain and appeal to …

The endocannabinoids system (ECS) has garnered considerable interest as a potential
therapeutic target in various carcinomas and cancer-related conditions alongside …

Cannabinoids and opioids share several pharmacologic properties and may act
synergistically. The potential pharmacokinetics and the safety of the combination in humans …

Cannabinoid CB1 and CB2 receptors are located at key sites involved in the relaying and
processing of noxious inputs. Both CB1 and CB2 receptor agonists have analgesic effects in …

A multitude of roles for the endogenous cannabinoid system has been proposed by recent
research efforts. A large number of endogenous cannabinoid neurotransmitters or …

For thousands of years, physicians and their patients employed cannabis as a therapeutic
agent. Despite this extensive historical usage, in the Western world, cannabis fell into …

Purpose Increased cannabis use and recent drug approvals pose new challenges for
avoiding drug interactions between cannabis products and conventional medications. This …

Among several pharmacological properties, analgesia is the most common feature shared
by either opioid or cannabinoid systems. Cannabinoids and opioids are distinct drug classes …

Although cannabis has been used for pain management for millennia, very few approved
cannabinoids are indicated for the treatment of pain and other medical symptoms …

Although prescribing information (PI) is often the initial source of information when
identifying potential drug-drug interactions, it may only provide a limited number of …