Abstract Interleukin-8 (CXCL8) was originally described as a chemokine whose main
function is the attraction of a polymorphonuclear inflammatory leukocyte infiltrate acting on …

Abstract Interleukin-8 (IL-8) is a proinflammatory CXC chemokine associated with the
promotion of neutrophil chemotaxis and degranulation. This chemokine activates multiple …

Tumor progression relies on the ability of cancer cells to effectively invade surrounding
tissues and propagate. Among the many mechanisms that contribute to tumor progression is …

Abstract Interleukin-8 (CXCL8) produced in the tumor microenvironment correlates with poor
response to checkpoint inhibitors and is known to chemoattract and activate …

Inflammatory responses play pivotal roles in cancer development, including tumor initiation,
promotion, progression, and metastasis. Cytokines are now recognized as important …

Endogenous cytokines are aberrantly produced in many cancers, and serve as autocrine
growth factors or indicators in immune response to the tumors. Hence, cytokine deregulation …

Abstract Purpose: Interleukin-8 (IL8) is a chemokine produced by malignant cells of multiple
cancer types. It exerts various functions in shaping protumoral vascularization and …

The aggressive nature of metastatic human cancer has been shown to be related to
numerous abnormalities in growth factors and their receptors. These perturbations confer a …

Interleukin-6 (IL-6) is a multifunctional cytokine which plays an important role in a wide
range of biologic activities in different types of cell including tumor cells. IL-6 is involved in …

It is generally thought that each cytokine exerts either immune stimulatory (inflammatory) or
immune inhibitory (antiinflammatory or regulatory) biological activities. However, multiple …