Aging is a complex process that features a functional decline in many organelles. Although
mitochondrial dysfunction is suggested as one of the determining factors of aging, the role of …

Mitochondria are key in the metabolism of aerobic organisms and in ageing progression and
age-related diseases. Mitochondria are essential for obtaining ATP from glucose and fatty …

Background: Mitochondrial dysfunction has long been considered a major contributor to
aging and age-related diseases. Harman's Mitochondrial Free Radical Theory of Aging …

Aging is a natural biological process in living organisms characterized by receding
bioenergetics. Mitochondria are crucial for cellular bioenergetics and thus an important …

Cellular senescence refers to a stress response aiming to preserve cellular and, therefore,
organismal homeostasis. Importantly, deregulation of mitochondrial homeostatic …

Age‐related changes in mitochondria are associated with decline in mitochondrial function.
With advanced age, mitochondrial DNA volume, integrity and functionality decrease due to …

Mitochondria are principal regulators of cellular function and metabolism through production
of ATP for energy homeostasis, maintenance of calcium homeostasis, regulation of …

Mitochondrial function is key for maintaining cellular health, while mitochondrial failure is
associated with various pathologies, including inherited metabolic disorders and age …

New molecular and in vivo findings regarding the onset and reversibility of mitochondrial
dysfunction with age indicate the potential: 1) for diagnostic tools to identify patients at risk …

Mitochondrial dysfunction may be a principal underlying event in aging, including the
degenerative diseases of aging such as brain degeneration. Mitochondria provide energy …