In Situ Nanopore Fabrication and Single-Molecule Sensing with Microscale Liquid Contacts

CE Arcadia, CC Reyes, JK Rosenstein - Acs Nano, 2017 - ACS Publications
In this article, we introduce a flexible technique for high-throughput solid-state nanopore
analysis of single biomolecules. By confining the electrolyte to a micron-scale liquid …

A low-noise solid-state nanopore platform based on a highly insulating substrate

MH Lee, A Kumar, KB Park, SY Cho, HM Kim… - Scientific reports, 2014 - nature.com
A solid-state nanopore platform with a low noise level and sufficient sensitivity to
discriminate single-strand DNA (ssDNA) homopolymers of poly-A40 and poly-T40 using …

Recent advances in integrated solid-state nanopore sensors

M Rahman, MJN Sampad, A Hawkins, H Schmidt - Lab on a Chip, 2021 - pubs.rsc.org
The advent of single-molecule probing techniques has revolutionized the biomedical and
life science fields and has spurred the development of a new class of labs-on-chip based on …

Integration of solid-state nanopores in microfluidic networks via transfer printing of suspended membranes

T Jain, RJS Guerrero, CA Aguilar, R Karnik - Analytical chemistry, 2013 - ACS Publications
Solid-state nanopores have emerged as versatile single-molecule sensors for applications
including DNA sequencing, protein unfolding, micro-RNA detection, label-free detection of …

Force-controlled formation of dynamic nanopores for single-biomolecule sensing and single-cell secretomics

T Schlotter, S Weaver, C Forró, D Momotenko… - ACS …, 2020 - ACS Publications
Nanopore sensing of single nucleotides has emerged as a promising single-molecule
technology for DNA sequencing and proteomics. Despite the conceptual simplicity of …

Nanopore‐based confined spaces for single‐molecular analysis

J Wang, J Yang, YL Ying… - Chemistry–An Asian …, 2019 - Wiley Online Library
The field of nanopore sensing at the single‐molecular level is in a “boom” period. Such
nanopores, which are either composed of biological materials or are fabricated from solid …

Solid-state nanopore sensors

L Xue, H Yamazaki, R Ren, M Wanunu… - Nature Reviews …, 2020 - nature.com
Nanopore-based sensors have established themselves as a prominent tool for solution-
based, single-molecule analysis of the key building blocks of life, including nucleic acids …

Evaluation of nanopore sensor design using electrical and optical analyses

LA Mayse, A Imran, Y Wang, M Ahmad, RA Oot… - ACS …, 2023 - ACS Publications
Nanopores are currently utilized as powerful tools for single-molecule protein sensing. The
reporting signal typically requires protein analytes to enter the nanopore interior, yet a class …

Improved measurement of proteins using a solid-state nanopore coupled with a hydrogel

S Acharya, A Jiang, C Kuo, R Nazarian, K Li, A Ma… - ACS …, 2020 - ACS Publications
Although resistive pulse sensing using solid-state nanopores is capable of single-molecule
sensitivity, previous work has shown that nanoparticles, such as proteins, pass through …

Solid-state nanopore fabrication by automated controlled breakdown

M Waugh, K Briggs, D Gunn, M Gibeault, S King… - Nature …, 2020 - nature.com
Solid-state nanopores are now well established as single-biomolecule sensors that hold
great promise as sensing elements in diagnostic and sequencing applications. However …