Inherited IL-12Rβ1 and TYK2 deficiencies impair both IL-12–and IL-23–dependent IFN-γ
immunity and are rare monogenic causes of tuberculosis, each found in less than 1/600,000 …

The pathogenesis of tuberculosis (TB) remains poorly understood, as no more than 5–10%
of individuals infected with Mycobacterium tuberculosis go on developing clinical disease …

Abstract The Jak, Tyk2, is activated in response to IL-12 and IFN-αβ and promotes IFN-γ
production by Th1-type CD4 cells. Mice deficient in Tyk2 function have been previously …

Abstract Tyrosine kinase-2 (Tyk2), a member of the Jak family of kinases, mediates the
signals triggered by various cytokines, including type I IFNs, IL-12, and IL-23. In the current …

Abstract Tyrosine kinase 2 (Tyk2), a member of the Jak kinase family, mediates signals
triggered by various cytokines, which are related to the pathogenesis of psoriasis. In this …

Tyrosine kinase 2 (TYK2) associates with interferon (IFN) alpha receptor, IL‐10 receptor (IL‐
10R) beta and other cytokine receptor subunits for signal transduction, in response to …

Autosomal recessive, complete TYK2 deficiency was previously described in a patient (P1)
with intracellular bacterial and viral infections and features of hyper-IgE syndrome (HIES) …

Evidence from genetic association and twin studies indicates that susceptibility to
tuberculosis (TB) is under genetic control. One gene implicated in susceptibility to TB is that …

The B10. Q/J strain of mice was serendipitously discovered to be highly susceptible to
infection by the intracellular protozoan parasite, Toxoplasma gondii but markedly resistant to …

Hundreds of patients with autosomal recessive, complete IL-12p40 or IL-12Rβ1 deficiency
have been diagnosed over the last 20 years. They typically suffer from invasive …