Pluripotent cells emerge as a naive founder population in the blastocyst, acquire capacity for
germline and soma formation, and then undergo lineage priming. Mouse embryonic stem …

Background Commitment in embryonic stem cells is often depicted as a binary choice
between alternate cell states, pluripotency and specification to a particular germ layer or …

Human naïve pluripotent stem cells (PSCs) share features with the pre-implantation epiblast.
They therefore provide an unmatched opportunity for characterising the developmental …

Pluripotent stem cells provide a platform to interrogate control elements that function to
generate all cell types of the body. Despite their utility for modeling development and …

Conventional human embryonic stem cells are considered to be primed pluripotent but can
be induced to enter a naive state. However, the transcriptional features associated with …

The pluripotency of mammalian early and late epiblast could be recapitulated by naïve
embryonic stem cells (ESCs) and primed epiblast stem cells (EpiSCs), respectively …

Embryonic stem cells (ESCs) of mice and humans have distinct molecular and biological
characteristics, raising the question of whether an earlier," naive" state of pluripotency may …

Mouse embryonic stem (ES) cells are locked into self-renewal by shielding from inductive
cues. Release from this ground state in minimal conditions offers a system for delineating …

Of all known cultured stem cell types, pluripotent stem cells (PSCs) sit atop the landscape of
developmental potency and are characterized by their ability to generate all cell types of an …

Naïve human pluripotent stem cells (hPSCs) provide a unique experimental platform of cell
fate decisions during pre-implantation development, but their lineage potential remains …