An overview of aryl hydrocarbon receptor ligands in the Last two decades (2002–2022): A medicinal chemistry perspective

L Lin, Y Dai, Y Xia - European Journal of Medicinal Chemistry, 2022 - Elsevier
The aryl hydrocarbon receptor (AhR), discovered 46 years ago, is a transcript factor member
of the basic helix-loop-helix Per-ARNT-SIM (bHLH-PAS) family deeply implicated in health …

Ligands and agonists of the aryl hydrocarbon receptor AhR: Facts and myths

L Sládeková, S Mani, Z Dvořák - Biochemical Pharmacology, 2023 - Elsevier
The aryl hydrocarbon receptor (AhR) belongs to the essential helix-loop-helix transcription
factors family. This receptor has a central role in determining host physiology and a variety of …

Development of novel CH223191-based antagonists of the aryl hydrocarbon receptor

EY Choi, H Lee, RWC Dingle, KB Kim… - Molecular pharmacology, 2012 - ASPET
Aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that regulates
genes involved in drug/xenobiotic metabolism, cell cycle progression, cell fate …

[HTML][HTML] Aryl hydrocarbon receptor (AHR) ligands as selective AHR modulators (SAhRMs)

S Safe, U Jin, H Park, RS Chapkin… - International journal of …, 2020 - mdpi.com
The aryl hydrocarbon receptor (AhR) was first identified as the intracellular protein that
bound and mediated the toxic effects of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin) …

The aryl hydrocarbon receptor in the crossroad of signalling networks with therapeutic value

ÁC Roman, JM Carvajal-Gonzalez, JM Merino… - Pharmacology & …, 2018 - Elsevier
The aryl hydrocarbon receptor (AhR) is well-known for its major contributions to the cellular
responses against environmental toxins and carcinogens. Notably, AhR has also emerged …

The AhR twist: ligand-dependent AhR signaling and pharmaco-toxicological implications

E Guyot, A Chevallier, R Barouki, X Coumoul - Drug discovery today, 2013 - Elsevier
The aryl hydrocarbon receptor (AhR) is a transcription factor which is activated by diverse
compounds and regulates the expression of xenobiotic metabolism genes. Recent studies …

Endogenous and exogenous ligands of aryl hydrocarbon receptor: current state of art

L Stejskalova, Z Dvorak, P Pavek - Current drug metabolism, 2011 - ingentaconnect.com
Aryl hydrocarbon receptor (AhR) is an important transcriptional regulator of drug
metabolizing enzymes that dominantly controls the expression of cytochrome P450 CYP1 …

The aryl hydrocarbon receptor: a multifunctional chemical sensor for host defense and homeostatic maintenance

K Kawajiri, Y Fujii-Kuriyama - Experimental animals, 2017 - jstage.jst.go.jp
The aryl hydrocarbon receptor (AHR) is a pivotal chemical sensor that transduces extrinsic
and intrinsic signals into cellular responses. AHR was originally thought to be involved in not …

Role of the aryl hydrocarbon receptor in carcinogenesis and potential as a drug target

S Safe, SO Lee, UH Jin - Toxicological Sciences, 2013 - academic.oup.com
The aryl hydrocarbon receptor (AHR) is highly expressed in multiple organs and tissues,
and there is increasing evidence that the AHR plays an important role in cellular …

The aryl hydrocarbon receptor cross-talks with multiple signal transduction pathways

A Puga, C Ma, JL Marlowe - Biochemical pharmacology, 2009 - Elsevier
Exposure to toxic polycyclic aromatic hydrocarbons raises a number of toxic and
carcinogenic responses in experimental animals and humans mediated for the most part by …