The genetic relationships between brain structure and schizophrenia
Genetic risks for schizophrenia are theoretically mediated by genetic effects on brain
structure but it has been unclear which genes are associated with both schizophrenia and …
structure but it has been unclear which genes are associated with both schizophrenia and …
Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept
Schizophrenia is a devastating psychiatric illness with high heritability. Brain structure and
function differ, on average, between people with schizophrenia and healthy individuals. As …
function differ, on average, between people with schizophrenia and healthy individuals. As …
Partitioning heritability analysis reveals a shared genetic basis of brain anatomy and schizophrenia
Schizophrenia is a devastating neurodevelopmental disorder with a complex genetic
etiology. Widespread cortical gray matter loss has been observed in patients and prodromal …
etiology. Widespread cortical gray matter loss has been observed in patients and prodromal …
Grey and white matter microstructure is associated with polygenic risk for schizophrenia
Recent discovery of approximately 270 common genetic variants associated with
schizophrenia has enabled polygenic risk scores (PRS) to be measured in the population …
schizophrenia has enabled polygenic risk scores (PRS) to be measured in the population …
Genetic association between schizophrenia and cortical brain surface area and thickness
Importance Schizophrenia is a complex heritable disorder associated with many genetic
variants, each with a small effect. While cortical differences between patients with …
variants, each with a small effect. While cortical differences between patients with …
Brain heterogeneity in schizophrenia and its association with polygenic risk
Importance Between-individual variability in brain structure is determined by gene-
environment interactions, possibly reflecting differential sensitivity to environmental and …
environment interactions, possibly reflecting differential sensitivity to environmental and …
[HTML][HTML] Boosting schizophrenia genetics by utilizing genetic overlap with brain morphology
D Van der Meer, AA Shadrin, K O'Connell, F Bettella… - Biological …, 2022 - Elsevier
Background Schizophrenia is a complex polygenic disorder with subtle, distributed
abnormalities in brain morphology. There are indications of shared genetic architecture …
abnormalities in brain morphology. There are indications of shared genetic architecture …
Predicting brain structure in population‐based samples with biologically informed genetic scores for schizophrenia
S Van der Auwera, K Wittfeld… - American Journal of …, 2017 - Wiley Online Library
Schizophrenia is associated with brain structural abnormalities including gray and white
matter volume reductions. Whether these alterations are caused by genetic risk variants for …
matter volume reductions. Whether these alterations are caused by genetic risk variants for …
Population-based mapping of polygenic risk for schizophrenia on the human brain: New opportunities to capture the dimensional aspects of severe mental disorders
LT Westlye, D Alnæs… - Biological …, 2019 - biologicalpsychiatryjournal.com
Schizophrenia remains one of the major enigmas in modern biomedicine. The lack of
knowledge about disease mechanisms has hampered the development of preventive …
knowledge about disease mechanisms has hampered the development of preventive …
The effects of psychosis risk variants on brain connectivity: a review
In light of observed changes in connectivity in schizophrenia and the highly heritable nature
of the disease, neural connectivity may serve as an important intermediate phenotype for …
of the disease, neural connectivity may serve as an important intermediate phenotype for …