If ever there were a truism then it would be that a completely protective Plasmodium
falciparum malaria vaccine is desperately needed. Our institute has devoted all its efforts …

Twenty years ago we reported the first synthetic peptide-based anti-malarial vaccine named
SPf66, which conferred limited protective efficacy in large-scale human field-trials. Our …

Introduction: Obtaining an effective antimalarial vaccine has represented one of the biggest
public health challenges over the last 50 years. Despite efforts by many laboratories around …

Rational strategies for obtaining malaria vaccine candidates should include not only a
proper selection of target antigens for antibody stimulation, but also a versatile molecular …

SIAP-1 and SIAP-2 are proteins which are implicated in early events involving Plasmodium
falciparum infection of the Anopheles mosquito vector and the human host. High affinity …

The aim of obtaining novel vaccine candidates against malaria and other transmissible
diseases can be partly based on selecting non-polymorphic peptides from relevant antigens …

Obtaining a highly effective malaria vaccine is a worldwide priority. The first approach aimed
at obtaining a malarial vaccine using synthetic peptides was a polymeric chimeric molecule …

• Introduction• P. falciparum invasion of RBCs• Merozoite proteins involved in invading
erythrocytes• Erythrocyte proteins involved in merozoite invasion• The state of current …

The review covers the functional and structural approach followed by our group for more
than 34 years in the search for a methodology that allows the rational design of chemically …

Plasmodium falciparum malaria is a disease causing high morbidity and mortality rates
worldwide, mainly in sub-Saharan Africa. Candidates have been identified for vaccines …