Calcium preconditioning elicits strong protection against ischemic injury via protein kinase C signaling pathway

H Miyawaki, X Zhou, M Ashraf - Circulation research, 1996 - Am Heart Assoc
We tested the hypothesis that elevation of [Ca2+] i during Ca2+ preconditioning (CPC) is a
strong activator of protein kinase C (PKC) and confers unique protection against ischemic …

Ca2+ as a Mediator of Ischemic Preconditioning

H Miyawaki, M Ashraf - Circulation research, 1997 - Am Heart Assoc
We tested the hypothesis that elevation of [Ca2+] i during ischemic preconditioning (IPC)
stimulates protein kinase C (PKC), which confers the protection against the ischemic injury …

Post-conditioning protects rat cardiomyocytes via PKCε-mediated calcium-sensing receptors

W Zhang, F Lu, Y Zhao, L Wang, Y Tian, Z Pan… - Biochemical and …, 2007 - Elsevier
Protein kinase C (PKC) plays a role in cardioprotection through reduction of intracellular
Ca2+ concentration [Ca2+] i during ischemic preconditioning (IPC). Cardioprotection against …

Calcium preconditioning in human myocardium

BS Cain, DR Meldrum, MD Xianzhong Meng… - The Annals of thoracic …, 1998 - Elsevier
Background. Ischemic stress and other protein kinase C (PKC)–linked receptor stimuli can
induce rapid cardiac protection against ischemia-reperfusion injury. We and others have …

Isoproterenol mimics calcium preconditioning-induced protection against ischemia

H Miyawaki, M Ashraf - American Journal of Physiology …, 1997 - journals.physiology.org
We tested the hypothesis that a transient increase in intracellular calcium concentration
([Ca2+] i) before prolonged ischemia triggers the activation of protein kinase C (PKC) …

Protein kinase C and preconditioning: role of the sarcoplasmic reticulum

K Yamamura, C Steenbergen… - American Journal of …, 2005 - journals.physiology.org
Activation of protein kinase C (PKC) is cardioprotective, but the mechanism (s) by which
PKC mediates protection is not fully understood. Inasmuch as PKC has been well …

Ischemic preconditioning translocates PKC-δ and-ε, which mediate functional protection in isolated rat heart

S Kawamura, KI Yoshida, T Miura… - American Journal …, 1998 - journals.physiology.org
Protein kinase C (PKC) plays an important role in mediating ischemic preconditioning (PC).
However, the relationship between PKC isoforms and PC is still uncertain. We analyzed …

[HTML][HTML] Cardiac preconditioning with calcium: clinically accessible myocardial protection

DR Meldrum, JC Cleveland Jr, BC Sheridan… - The Journal of Thoracic …, 1996 - Elsevier
Cardiac preconditioning is mediated by protein kinase C. Although endogenous calcium is a
potent stimulus of protein kinase C, it remains unknown whether preischemic administration …

Ischemic and anesthetic preconditioning reduces cytosolic [Ca2+] and improves Ca2+responses in intact hearts

J An, SG Varadarajan, E Novalija… - American Journal of …, 2001 - journals.physiology.org
Ca+ loading during reperfusion after myocardial ischemia is linked to reduced cardiac
function. Like ischemic preconditioning (IPC), a volatile anesthetic given briefly before …

Role of Intracellular Ca2+ in Activation of Protein Kinase C During Ischemic Preconditioning

K Node, M Kitakaze, H Sato, T Minamino… - Circulation, 1997 - Am Heart Assoc
Background Activation of protein kinase C plays an important role in ischemic
preconditioning. Given that protein kinase C is activated by an increase in the intracellular …