During human pre-implantation development a totipotent zygote develops into a competent
blastocyst ready for implantation 7 days post fertilisation (dpf). The segregation into …

Early mammal embryogenesis starts with oocyte fertilization, giving rise to the zygote. The
events that the newly formed zygote surpasses are crucial to the embryo developmental …

Understanding the mechanisms underlying the first cell differentiation events in human
preimplantation development is fundamental for defining the optimal conditions for IVF …

In mammals, the first cell-fate decision occurs during preimplantation embryo development
when the inner cell mass (ICM) and trophectoderm (TE) lineages are established. The ICM …

First cell fate determination plays crucial roles in cell specification during early phases of
embryonic development. Three classical concepts have been proposed to explain the …

During mammalian preimplantation development, the fertilised egg gives rise to a group of
pluripotent embryonic cells, the epiblast, and to the extraembryonic lineages that support the …

In the mouse embryo, asymmetric divisions during the 8-16 cell division generate two cell
types, polar and apolar cells, that are allocated to outer and inner positions, respectively …

During preimplantation development, mouse embryos form two types of cells, the
trophoectoderm (TE) and inner cell mass (ICM), by the early blastocyst stage. This process …

During human preimplantation development the totipotent zygote divides and undergoes a
number of changes that lead to the first lineage differentiation in the blastocyst displaying …

In preimplantation mouse embryos, the Hippo signaling pathway plays a central role in
regulating the fates of the trophectoderm (TE) and the inner cell mass (ICM). In early …