Eletters TO THE EDITOR highlighting the role of toll-like receptors (TLRs), in sepsis
pathogenesis. We would like to highlight several related points that were not covered in the …

There is no proven pharmacological intervention for sepsis. This is not for want of trying–
dozens of therapies have been studied in clinical trials. Nor is it because of ignorance …

Sepsis remains to be a significant health care issue associated with high mortality and
healthcare cost, despite the extensive effort to better understand the pathophysiology of the …

Sepsis and septic shock represent an enormous global burden, affecting millions of
individuals each year. 1, 2 Similar to other medical emergencies, such as myocardial …

Editors Wiersinga and Seymour provide an aptly named Handbook of Sepsis: a compact
and concise review of this common presentation. The Handbook, which can be mistaken for …

Sepsis is frequently associated with abnormal coagulation test results, with deviations
ranging from delicate activation of coagulation that can only be recognized by highly …

Sepsis-3 shifts the focus from a noninfectious inflammatory process and an emphasis on a
dysregulated host response to infection. Hyperchloremic crystalloid resuscitation is …

Severe sepsis is a deadly, under-appreciated, under-diagnosed, under-investigated yet
frighteningly common syndrome. 1–3 Data now over a decade old indicate that it kills nearly …

Sepsis and septic shock represent a continuum of illness caused by infection and the
subsequent somatic inflammatory response to a pathogen. This continuum of conditions …

As of 2017, the World Health Organization has made the recognition, prevention, and
management of sepsis a global health priority. 1 Hippocrates considered the term a …