Drug Repurposing for Candidate SARS-CoV-2 Main Protease Inhibitors by a Novel In Silico Method

M Sencanski, V Perovic, SB Pajovic, M Adzic… - Molecules, 2020 - mdpi.com
The SARS-CoV-2 outbreak caused an unprecedented global public health threat, having a
high transmission rate with currently no drugs or vaccines approved. An alternative powerful …

Drugs Repurposing Using QSAR, Docking and Molecular Dynamics for Possible Inhibitors of the SARS-CoV-2 Mpro Protease

E Tejera, CR Munteanu, A López-Cortés… - Molecules, 2020 - mdpi.com
Wuhan, China was the epicenter of the first zoonotic transmission of the severe acute
respiratory syndrome coronavirus clade 2 (SARS-CoV-2) in December 2019 and it is the …

In silico Drug Repurposing for COVID‐19: Targeting SARS‐CoV‐2 Proteins through Docking and Consensus Ranking

CN Cavasotto, JI Di Filippo - Molecular informatics, 2021 - Wiley Online Library
In December 2019, an infectious disease caused by the coronavirus SARS‐CoV‐2
appeared in Wuhan, China. This disease (COVID‐19) spread rapidly worldwide, and on …

[HTML][HTML] Drug repurposing approach against novel coronavirus disease (COVID-19) through virtual screening targeting SARS-CoV-2 main protease

KH Chowdhury, MR Chowdhury, S Mahmud, AM Tareq… - Biology, 2021 - mdpi.com
Abstract Novel coronavirus disease (COVID-19) was identified from China in December
2019 and spread rapidly through human-to-human transmission, affecting so many people …

[HTML][HTML] Aminoglycosides as potential inhibitors of SARS-CoV-2 main protease: an in silico drug repurposing study on FDA-approved antiviral and anti-infection …

MZ Ahmed, Q Zia, A Haque, AS Alqahtani… - Journal of Infection and …, 2021 - Elsevier
Background The emergence and spread of SARS-CoV-2 throughout the world has created
an enormous socioeconomic impact. Although there are several promising drug candidates …

Drug repurposing against SARS-CoV-2 using E-pharmacophore based virtual screening, molecular docking and molecular dynamics with main protease as the target

KG Arun, CS Sharanya, J Abhithaj… - Journal of …, 2021 - Taylor & Francis
Since its first report in December 2019 from China, the COVID-19 pandemic caused by the
beta-coronavirus SARS-CoV-2 has spread at an alarming pace infecting about 5.59 million …

Finding potent inhibitors for COVID-19 main protease (Mpro): an in silico approach using SARS-CoV-3CL protease inhibitors for combating CORONA

M Motiwale, NS Yadav, S Kumar… - Journal of …, 2022 - Taylor & Francis
SARS-CoV-2 is liable for the worldwide coronavirus disease (COVID-19) exigency. This
pandemic created the need for all viable treatment strategies available in the market. In this …

Virtual screening of approved drugs as potential SARS-CoV-2 main protease inhibitors

A Jimenez-Alberto, RM Ribas-Aparicio… - … biology and chemistry, 2020 - Elsevier
The global emergency caused by COVID-19 makes the discovery of drugs capable of
inhibiting SARS-CoV-2 a priority, to reduce the mortality and morbidity of this disease …

[HTML][HTML] In silico prediction of potential inhibitors for the main protease of SARS-CoV-2 using molecular docking and dynamics simulation based drug-repurposing

Y Kumar, H Singh, CN Patel - Journal of infection and public health, 2020 - Elsevier
Background The rapidly enlarging COVID-19 pandemic caused by the novel SARS-corona
virus-2 is a global public health emergency of an unprecedented level. Unfortunately no …

In silico identification of potent FDA approved drugs against Coronavirus COVID-19 main protease: A drug repurposing approach

D Kumar, V Chandel, S Raj, B Rathi - Chemical Biology Letters, 2020 - pubs.iscience.in
Abstract The Coronavirus COVID-19 Main Proteases play critical role in the propagation of
the Novel Coronavirus (COVID-19). We have applied a bioinformatics approach of drug …