Obesity cardiomyopathy: evidence, mechanisms, and therapeutic implications

J Ren, NN Wu, S Wang, JR Sowers… - Physiological …, 2021 - journals.physiology.org
The prevalence of heart failure is on the rise and imposes a major health threat, in part, due
to the rapidly increased prevalence of overweight and obesity. To this point …

Obesity cardiomyopathy: pathogenesis and pathophysiology

C Wong, TH Marwick - Nature Clinical Practice Cardiovascular …, 2007 - nature.com
Obesity is becoming a worldwide phenomenon. Myocardial changes associated with the
obese state are increasingly recognized, independent of hypertension, obstructive sleep …

Obesity cardiomyopathy: diagnosis and therapeutic implications

C Wong, TH Marwick - Nature Clinical Practice Cardiovascular …, 2007 - nature.com
Obesity is associated with an increased risk of heart failure. Apparently healthy obese
individuals can, however, exhibit subclinical left ventricular dysfunction. The use of …

Obesity and heart failure: epidemiology, pathophysiology, clinical manifestations, and management

MA Alpert, CJ Lavie, H Agrawal, KB Aggarwal… - Translational …, 2014 - Elsevier
Obesity is a risk factor for heart failure (HF) in both men and women. The mortality risk of
overweight and class I and II obese adults with HF is lower than that of normal weight or …

Obesity cardiomyopathy: pathophysiology and evolution of the clinical syndrome

MA Alpert - The American journal of the medical sciences, 2001 - Elsevier
Obesity produces an increase in total blood volume and cardiac output because of the high
metabolic activity of excessive fat. In moderate to severe cases of obesity, this may lead to …

Cardiac remodeling in obesity

ED Abel, SE Litwin, G Sweeney - Physiological reviews, 2008 - journals.physiology.org
The dramatic increase in the prevalence of obesity and its strong association with
cardiovascular disease have resulted in unprecedented interest in understanding the effects …

Obesity and the heart

MA Alpert, MW Hashimi - The American journal of the medical sciences, 1993 - Elsevier
Obesity can result in alterations in cardiac structure and function even in the absence of
systemic hypertension and underlying organic heart disease. Increased total blood volume …

Mechanisms of heart failure in obesity

IA Ebong, DC Goff Jr, CJ Rodriguez, H Chen… - Obesity research & …, 2014 - Elsevier
Heart failure is a leading cause of morbidity and mortality and its prevalence continues to
rise. Because obesity has been linked with heart failure, the increasing prevalence of …

Impact of obesity and weight loss on cardiac performance and morphology in adults

MA Alpert, J Omran, A Mehra, S Ardhanari - Progress in cardiovascular …, 2014 - Elsevier
Obesity, particularly severe obesity is capable of producing hemodynamic alterations that
predispose to changes in cardiac morphology and ventricular function. These include …

Heart failure and obesity: The latest pandemic

E Aryee, B Ozkan, CE Ndumele - Progress in Cardiovascular Diseases, 2023 - Elsevier
The marked rise in rates of obesity, which is most prominent among individuals from socio-
economically disadvantaged circumstances, has been a powerful contributor to the rising …