Mesial temporal lobe epilepsy (MTLE), the most common form of focal epilepsy in adults, is
often refractory to medication and associated with hippocampal sclerosis. Deep brain …

Mesial temporal lobe epilepsy (MTLE) is the most common form of focal, pharmacoresistant
epilepsy in adults and is often associated with hippocampal sclerosis. Here, we established …

In patients with pharmacologically intractable epilepsy who are not eligible for surgery, deep
brain stimulation is currently under evaluation as an alternative treatment. Optimal …

Brain stimulation with low-frequency stimulation (LFS) is emerging as an alternative
treatment for refractory epilepsy. The present study aimed to investigate the effects of LFS …

Objective Surgical resection of the temporal lobe is an effective treatment for medically
intractable temporal lobe epilepsy, but can cause memory impairment. Deep brain …

Key points• Deep brain electrical stimulation (DBS) is a promising treatment for mesial
temporal lobe epilepsy (MTLE). However, treatment optimization and clinical application are …

Low-frequency stimulation (LFS) is emerging as a new option for the treatment of epilepsy.
The present study was designed to determine whether there is a crucial period for the …

Electrical stimulation for applications in epilepsy has been attempted in multiple brain
re4gions using high-or low-frequency stimulation protocols. Data suggest that specific …

Epilepsy is a common neurological disease. About 30% of epileptic patients develop
resistance to antiepileptic drugs (AEDs), and are considered to have refractory or …

Low-frequency stimulation (LFS) has been considered as an option for the treatment of
intractable epilepsy. However, previous data showed that LFS of certain brain regions only …