Microglial activation and tau propagate jointly across Braak stages
Compelling experimental evidence suggests that microglial activation is involved in the
spread of tau tangles over the neocortex in Alzheimer's disease (AD). We tested the …
spread of tau tangles over the neocortex in Alzheimer's disease (AD). We tested the …
Activated microglia mitigate Aβ-associated tau seeding and spreading
In Alzheimer's disease (AD) models, AD risk variants in the microglial-expressed TREM2
gene decrease Aβ plaque–associated microgliosis and increase neuritic dystrophy as well …
gene decrease Aβ plaque–associated microgliosis and increase neuritic dystrophy as well …
Microglial activation protects against accumulation of tau aggregates in nondemented individuals with underlying Alzheimer's disease pathology
JB Pereira, S Janelidze, O Strandberg, CD Whelan… - Nature aging, 2022 - nature.com
The role of microglia in tau accumulation is currently unclear but could provide an important
insight into the mechanisms underlying Alzheimer's disease (AD). Here, we measured the …
insight into the mechanisms underlying Alzheimer's disease (AD). Here, we measured the …
Astrocyte reactivity influences amyloid-β effects on tau pathology in preclinical Alzheimer's disease
An unresolved question for the understanding of Alzheimer's disease (AD) pathophysiology
is why a significant percentage of amyloid-β (Aβ)-positive cognitively unimpaired (CU) …
is why a significant percentage of amyloid-β (Aβ)-positive cognitively unimpaired (CU) …
TREM2 function impedes tau seeding in neuritic plaques
Variants in the triggering receptor expressed on myeloid cells 2 (TREM2) have been
associated with increased risk for sporadic, late-onset Alzheimer's disease. Here we show …
associated with increased risk for sporadic, late-onset Alzheimer's disease. Here we show …
Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer's disease
Glia have been implicated in Alzheimer's disease (AD) pathogenesis. Variants of the
microglia receptor triggering receptor expressed on myeloid cells 2 (TREM2) increase AD …
microglia receptor triggering receptor expressed on myeloid cells 2 (TREM2) increase AD …
Chronic TREM2 activation exacerbates Aβ-associated tau seeding and spreading
N Jain, CA Lewis, JD Ulrich… - Journal of Experimental …, 2022 - rupress.org
Variants in the triggering receptor expressed on myeloid cells 2 (TREM2) gene are
associated with increased risk for late-onset AD. Genetic loss of or decreased TREM2 …
associated with increased risk for late-onset AD. Genetic loss of or decreased TREM2 …
Four distinct trajectories of tau deposition identified in Alzheimer's disease
Alzheimer's disease (AD) is characterized by the spread of tau pathology throughout the
cerebral cortex. This spreading pattern was thought to be fairly consistent across individuals …
cerebral cortex. This spreading pattern was thought to be fairly consistent across individuals …
Amyloid-β plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation
Z He, JL Guo, JD McBride, S Narasimhan, H Kim… - Nature medicine, 2018 - nature.com
Alzheimer's disease (AD) is characterized by extracellular amyloid-β (Aβ) plaques and
intracellular tau inclusions. However, the exact mechanistic link between these two AD …
intracellular tau inclusions. However, the exact mechanistic link between these two AD …
Earlier Alzheimer's disease onset is associated with tau pathology in brain hub regions and facilitated tau spreading
In Alzheimer's disease (AD), younger symptom onset is associated with accelerated disease
progression and tau spreading, yet the mechanisms underlying faster disease manifestation …
progression and tau spreading, yet the mechanisms underlying faster disease manifestation …