The primary role of red blood cells (RBCs) is to transport oxygen to the tissues and carbon
dioxide to the lungs. However, emerging evidence suggests an important role of the RBC …

Significance: Recent clinical evidence identified anemia to be correlated with severe
complications of cardiovascular disease (CVD) such as bleeding, thromboembolic events …

The fundamental physiology of circulating red blood cells (RBCs) and platelets involving
regulation of oxygen transport and hemostasis, respectively, are well-described in the …

Diabetes Mellitus (DM) is a complex metabolic disorder associated with multiple
microvascular complications leading to nephropathy, retinopathy, and neuropathy. Mounting …

Nitric oxide (NO) is a signaling molecule of major importance modulating not only the
function of the vascular wall but also that of blood cells, such as platelets and leukocytes …

Erythrocytes regulate vascular function through the modulation of oxygen delivery and the
scavenging and generation of nitric oxide (NO). First, hemoglobin inside the red blood cell …

Nitric oxide (NO) regulates normal vasomotor tone and modulates important homeostatic
functions such as thrombosis, cellular proliferation, and adhesion molecule expression …

Red blood cells (RBC) have been considered almost exclusively as a transporter of
metabolic gases and nutrients for the tissues. It is an accepted dogma that RBCs take up …

Human red blood cells (RBC) are highly differentiated cells that have lost all organelles and
most intracellular machineries during their maturation process. RBC are fundamental for the …

Background & aims Nitric oxide bioactivity (NO) from endothelial NO synthase (eNOS)
importantly contributes to the maintenance of vascular homeostasis, and reduced eNOS …