Alzheimer's disease (AD) is the most common cause of dementia in the elderly. Although its
pathogenesis remains unclear, studies have indicated microglia-mediated …

Neurodegenerative disease is a disease state in which neurons in the spinal cord and brain
are lost. Studies show that sustained neuroinflammatory reactions release toxic factors …

Background Alzheimer's disease (AD) is a major clinical problem, but there is a distinct lack
of effective therapeutic drugs for this disease. We investigated the potential therapeutic …

Microglia-mediated neuroinflammation plays an important role in Alzheimer's disease
development. Resveratrol, a natural polyphenol from the Japanese knotweed (Polygonum …

Reducing β amyloid‐(Aβ‐) induced microglial activation is believed to be effective in treating
Alzheimer's disease (AD). Microglia can be activated into classic activated state (M1 state) or …

Background Activated microglia‐mediated inflammation plays a key role in the pathogenesis
of Alzheimer's disease (AD). In addition, chronic activation of NLRP 3 inflammasomes …

Neuroinflammation is a specific or nonspecific immunological reaction in the central nervous
system that is induced by microglia activation. Appropriate regulation of activated microglial …

Neuroinflammatory microenvironment, regulating neurite regrowth and neuronal survival,
plays a critical role in Alzheimer's disease (AD). During neuroinflammation, microglia are …

Adenosine 5′‐monophosphate‐activated protein kinase (AMPK) is a key regulator of
cellular energy homeostasis via modulating metabolism of glucose, lipid, and protein. In …

Cornuside is an iridoid glycoside from Cornus officinalis, with the activities of anti-
inflammatory, antioxidant, anti-mitochondrial dysfunction, and neuroprotection. In the …