Cholesterol and COVID-19—therapeutic opportunities at the host/virus interface during cell entry

T Grewal, MKL Nguyen, C Buechler - Life Science Alliance, 2024 - life-science-alliance.org
The rapid development of vaccines to combat severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infections has been critical to reduce the severity of COVID-19 …

SARS-CoV-2 requires cholesterol for viral entry and pathological syncytia formation

DW Sanders, CC Jumper, PJ Ackerman, D Bracha… - Elife, 2021 - elifesciences.org
Many enveloped viruses induce multinucleated cells (syncytia), reflective of membrane
fusion events caused by the same machinery that underlies viral entry. These syncytia are …

Potential COVID-19 therapeutics from a rare disease: weaponizing lipid dysregulation to combat viral infectivity

SL Sturley, T Rajakumar, N Hammond, K Higaki… - Journal of lipid …, 2020 - ASBMB
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory
syndrome coronavirus (SARS-CoV)-2 has resulted in the death of more than 328,000 …

Lipid raft integrity and cellular cholesterol homeostasis are critical for SARS-CoV-2 entry into cells

A Bakillah, FA Hejji, A Almasaud, HA Jami, A Hawwari… - Nutrients, 2022 - mdpi.com
Lipid rafts in cell plasma membranes play a critical role in the life cycle of many viruses.
However, the involvement of membrane cholesterol-rich lipid rafts in the entry of severe …

Cholesterol-modifying drugs in COVID-19

NM Schmidt, PAC Wing, JA McKeating… - Oxford open …, 2020 - academic.oup.com
Infection with severe acute respiratory syndrom coronavirus 2 (SARS-CoV-2) is more likely
to lead to poor outcomes in the elderly and those with cardiovascular disease, obesity or …

Cholesterol, lipoproteins, and COVID-19: Basic concepts and clinical applications

E Kočar, T Režen, D Rozman - … et Biophysica Acta (BBA)-Molecular and …, 2021 - Elsevier
Cholesterol is being recognized as a molecule involved in regulating the entry of the SARS-
CoV-2 virus into the host cell. However, the data about the possible role of cholesterol …

Cholesterol-rich lipid rafts as platforms for SARS-CoV-2 entry

SN Palacios-Rápalo, LA De Jesus-Gonzalez… - Frontiers in …, 2021 - frontiersin.org
Since its appearance, the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2),
the causal agent of Coronavirus Disease 2019 (COVID-19), represents a global problem for …

Coronavirus infection and cholesterol metabolism

J Dai, H Wang, Y Liao, L Tan, Y Sun, C Song… - Frontiers in …, 2022 - frontiersin.org
Host cholesterol metabolism remodeling is significantly associated with the spread of human
pathogenic coronaviruses, suggesting virus-host relationships could be affected by …

The role of high cholesterol in SARS-CoV-2 infectivity

H Wang, Z Yuan, MA Pavel, SM Jablonski… - Journal of Biological …, 2023 - ASBMB
Coronavirus disease 2019 (COVID-19) is a respiratory infection caused by severe acute
respiratory syndrome coronavirus 2. The virus binds to angiotensinogen converting enzyme …

Targeting Scavenger Receptor Type B-1 (SR-B1) and Cholesterol Inhibits Entry of SARS-CoV-2 Pseudovirus in Cell Culture

SE Henrich, KM McMahon, N Palacio, P Bhalla… - BioRxiv, 2020 - biorxiv.org
The novel human coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2), emerged in Wuhan, China in late 2019 and has now caused a global pandemic …