Bioinformatic and experimental analysis of T cell immune reactivity to SARS-CoV-2 and its variants

A Tarke, A Grifoni, A Sette - Frontiers in Bioinformatics, 2022 - frontiersin.org
Definition of the T cells responses to SARS-CoV-2 and associated variants is critical to
understanding the complexity of adaptive immunity against SARS-CoV-2 infection. Several …

A bioinformatic analysis of T-cell epitope diversity in SARS-CoV-2 variants: association with COVID-19 clinical severity in the United States population

GJ Kim, JH Elnaggar, M Varnado, AK Feehan… - Frontiers in …, 2024 - frontiersin.org
Long-term immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) requires the identification of T-cell epitopes affecting host immunogenicity. In this …

[HTML][HTML] From Alpha to omicron: The response of T cells

A Grifoni, A Sette - Current research in immunology, 2022 - Elsevier
It is critically important to understand how the adaptive immune response, elicited by
vaccination or infection, recognizes SARS-CoV-2. This is especially true when considering …

[HTML][HTML] Impact of SARS-CoV-2 variants on the total CD4+ and CD8+ T cell reactivity in infected or vaccinated individuals

A Tarke, J Sidney, N Methot, ED Yu, Y Zhang… - Cell Reports …, 2021 - cell.com
The emergence of SARS-CoV-2 variants with evidence of antibody escape highlight the
importance of addressing whether the total CD4+ and CD8+ T cell recognition is also …

A systems approach evaluating the impact of SARS-CoV-2 variant of concern mutations on CD8+ T cell responses

PR Buckley, CH Lee, A Antanaviciute… - Immunotherapy …, 2023 - academic.oup.com
T cell recognition of SARS-CoV-2 antigens after vaccination and/or natural infection has
played a central role in resolving SARS-CoV-2 infections and generating adaptive immune …

Current understanding of T cell immunity against SARS-CoV-2

X Lu, S Yamasaki - Inflammation and Regeneration, 2022 - Springer
As an important part of adaptive immunity, T cells are indispensable in the defense against
pathogens including viruses. SARS-CoV-2 is a new human coronavirus that occurred at the …

[HTML][HTML] In silico analysis of mutant epitopes in new SARS-CoV-2 lineages suggest global enhanced CD8+ T cell reactivity and also signs of immune response escape

MAM Pretti, RG Galvani, NM Scherer, AS Farias… - Infection, Genetics and …, 2022 - Elsevier
SARS-CoV-2 variants of concern have emerged since the COVID-19 outburst, notably the
lineages detected in the UK, South Africa, and Brazil. Their increased transmissibility and …

Next-generation sequencing of T and B cell receptor repertoires from COVID-19 patients showed signatures associated with severity of disease

C Schultheiß, L Paschold, D Simnica, M Mohme… - Immunity, 2020 - cell.com
We profiled adaptive immunity in COVID-19 patients with active infection or after recovery
and created a repository of currently> 14 million B and T cell receptor (BCR and TCR) …

Machine learning analysis of humoral and cellular responses to SARS-CoV-2 infection in young adults

R Marcinkevics, PN Silva, AK Hankele… - Frontiers in …, 2023 - frontiersin.org
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces B and T cell
responses, contributing to virus neutralization. In a cohort of 2,911 young adults, we …

Machine-learning-assisted analysis of TCR profiling data unveils cross-reactivity between SARS-CoV-2 and a wide spectrum of pathogens and other diseases

GK Georgakilas, AP Galanopoulos, Z Tsinaris, M Kyritsi… - Biology, 2022 - mdpi.com
Simple Summary For the last two years, COVID-19 has been rigorously studied aiming to
identify novel prognostic and therapeutic avenues. Recently, T cell receptor profiling has …