Abstract Dysregulation of Th17 and Treg cells contributes to the pathophysiology of many
autoimmune diseases. Herein, we show that itaconate, an immunomodulatory metabolite …

Accumulating evidence indicates that metabolism reprogramming is critically important to T
cell differentiation, and manipulating metabolic pathways in T cells can shape their fate and …

The interplay of the immune system with other aspects of physiology is continually being
revealed and in some cases studied in considerable mechanistic detail. A prime example is …

Abstract Interleukin-17 (IL-17)-secreting T cells of the T helper 17 (TH17) lineage play a
pathogenic role in multiple inflammatory and autoimmune conditions and thus represent a …

Experimental autoimmune encephalomyelitis (EAE) is a Th1 and Th17 cell-mediated
autoimmune disease of the CNS. IDO and tryptophan metabolites have inhibitory effects on …

Abstract IL-17-producing TH 17 cells have been associated with autoimmune diseases such
as multiple sclerosis (MS), psoriasis, Crohn's disease, and ulcerative colitis (Han et al …

Among the subset of T helper cells, Th17 cells are known to play a crucial role in the
pathogenesis of various autoimmune disorders, such as psoriasis, rheumatoid arthritis …

Understanding metabolic pathways that regulate Th17 development is important to broaden
therapeutic options for Th17-mediated autoimmunity. Here, we report a pivotal role of …

Abstract T helper 17 (Th17) cells are IL-17-producing CD4 T cells that play a crucial role in
autoimmune diseases. IL-17 is a key cytokine for host protection against mucosal and skin …

Glutaminolysis is a well-known source of energy for effector T cells but its contribution to
each T cell subset and the mechanisms which are responsible for the control of involved …