[HTML][HTML] Could SARS-CoV-2 spike protein be responsible for long-COVID syndrome?

TC Theoharides - Molecular Neurobiology, 2022 - Springer
SARS-CoV-2 infects cells via its spike protein binding to its surface receptor on target cells
and results in acute symptoms involving especially the lungs known as COVID-19. However …

[HTML][HTML] Long-term sequelae of COVID-19 in experimental mice

MJ Paidas, DS Cosio, S Ali, NS Kenyon… - Molecular …, 2022 - Springer
We recently reported acute COVID-19 symptoms, clinical status, weight loss, multi-organ
pathological changes, and animal death in a murine hepatitis virus-1 (MHV-1) coronavirus …

[HTML][HTML] Role of SARS-CoV-2 spike-protein-induced activation of microglia and mast cells in the pathogenesis of neuro-COVID

TC Theoharides, D Kempuraj - Cells, 2023 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus
disease 2019 (COVID-19). About 45% of COVID-19 patients experience several symptoms a …

[PDF][PDF] Be aware of SARS-CoV-2 spike protein: There is more than meets the eye

TC Theoharides, P Conti - J Biol Regul Homeost Agents, 2021 - mastcellmaster.com
The COVID-19 pandemic necessitated the rapid production of vaccines aimed at the
production of neutralizing antibodies against the COVID-19 spike protein required for the …

[HTML][HTML] Penetration of the SARS-CoV-2 spike protein across the blood–brain barrier, as revealed by a combination of a human cell culture model system and optical …

D Petrovszki, FR Walter, JP Vigh, A Kocsis, S Valkai… - Biomedicines, 2022 - mdpi.com
Since the outbreak of the global pandemic caused by severe acute respiratory coronavirus 2
(SARS-CoV-2), several clinical aspects of the disease have come into attention. Besides its …

SARS-CoV-2 spike protein accumulation in the skull-meninges-brain axis: Potential implications for long-term neurological complications in post-COVID-19

Z Rong, H Mai, S Kapoor, VG Puelles, J Czogalla… - BioRxiv, 2023 - biorxiv.org
ABSTRACT Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory
syndrome coronavirus type 2 (SARS-CoV-2), has been associated mainly with a range of …

[HTML][HTML] SARS-CoV-2 spike protein induces cognitive deficit and anxiety-like behavior in mouse via non-cell autonomous hippocampal neuronal death

J Oh, WH Cho, E Barcelon, KH Kim, J Hong, SJ Lee - Scientific reports, 2022 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is accompanied
by chronic neurological sequelae such as cognitive decline and mood disorder, but the …

[HTML][HTML] SARS-CoV-2 spike protein elicits cell signaling in human host cells: implications for possible consequences of COVID-19 vaccines

YJ Suzuki, SG Gychka - Vaccines, 2021 - mdpi.com
The world is suffering from the coronavirus disease 2019 (COVID-19) pandemic caused by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 uses its …

Seeding brain protein aggregation by SARS-CoV-2 as a possible long-term complication of COVID-19 infection

O Tavassoly, F Safavi, I Tavassoly - ACS Chemical Neuroscience, 2020 - ACS Publications
Postinfection complications of coronavirus disease 2019 (COVID-19) are still unknown, and
one of the long-term concerns in infected people are brain pathologies. The question is that …

Endothelial cell damage is the central part of COVID-19 and a mouse model induced by injection of the S1 subunit of the spike protein

GJ Nuovo, C Magro, T Shaffer, H Awad, D Suster… - Annals of diagnostic …, 2021 - Elsevier
Neurologic complications of symptomatic COVID-19 are common. Brain tissues from 13
autopsies of people who died of COVID-19 were examined. Cultured endothelial and …