Cytokine storm syndrome

RQ Cron, G Goyal, WW Chatham - Annual Review of Medicine, 2023 - annualreviews.org
Cytokine storm syndrome (CSS), which is frequently fatal, has garnered increased attention
with the ongoing coronavirus pandemic. A variety of hyperinflammatory conditions …

COVID-19-associated cytokine storm syndrome and diagnostic principles: an old and new Issue

X Yongzhi - Emerging microbes & infections, 2021 - Taylor & Francis
ABSTRACT SARS-CoV-2 has claimed 2,137,908 lives in more than a year. Some COVID-19
patients experience sudden and rapid deterioration with the onset of fatal cytokine storm …

Cytokine storm

DC Fajgenbaum, CH June - New England Journal of Medicine, 2020 - Mass Medical Soc
Cytokine Storm Cytokine storm, a life-threatening disorder involving cytokine elevations and
immune-cell hyperactivation, has various causes and is characterized by constitutional …

Macrophage activation-like syndrome: a distinct entity leading to early death in sepsis

E Karakike, EJ Giamarellos-Bourboulis - Frontiers in immunology, 2019 - frontiersin.org
Hemophagocytic lymphohistocytosis (HLH) is characterized by fulminant cytokine storm
leading to multiple organ dysfunction and high mortality. HLH is classified into familial …

Highways to hell: Mechanism-based management of cytokine storm syndromes

SW Canna, RQ Cron - Journal of Allergy and Clinical Immunology, 2020 - Elsevier
Since the first textbook devoted to cytokine storm syndromes (CSSs) was published in 2019,
the world has changed dramatically and the term's visibility has broadened. Herein, we …

The genetics of macrophage activation syndrome

GS Schulert, RQ Cron - Genes & Immunity, 2020 - nature.com
Macrophage activation syndrome (MAS), or secondary hemophagocytic lymphohistiocytosis
(HLH), is a cytokine storm syndrome associated with multi-organ system dysfunction and …

Clinical features of cytokine storm syndrome

M Shimizu - Cytokine storm syndrome, 2019 - Springer
The common clinical features of cytokine storm syndrome (CSS) are sustained fever,
splenomegaly, hepatomegaly with liver dysfunction, lymphadenopathy, coagulopathy …

[HTML][HTML] Cytokine storm syndrome in severe COVID-19

P Ruscitti, O Berardicurti, A Iagnocco… - Autoimmunity …, 2020 - ncbi.nlm.nih.gov
Dear Editor, we read with interest the article by McGonagle et al., which has been recently
published on this Journal [1]. This article highlights the role of pro-inflammatory cytokines in …

JAK/STAT pathway inhibition sensitizes CD8 T cells to dexamethasone-induced apoptosis in hyperinflammation

LK Meyer, KC Verbist, S Albeituni… - Blood, The Journal …, 2020 - ashpublications.org
Cytokine storm syndromes (CSS) are severe hyperinflammatory conditions characterized by
excessive immune system activation leading to organ damage and death. Hemophagocytic …

Weathering the COVID-19 storm: Lessons from hematologic cytokine syndromes

JT England, A Abdulla, CM Biggs, AYY Lee, KA Hay… - Blood Reviews, 2021 - Elsevier
A subset of patients with severe COVID-19 develop profound inflammation and multi-organ
dysfunction consistent with a “Cytokine Storm Syndrome”(CSS). In this review we compare …