[HTML][HTML] GPRC5D-targeted CAR T cells for myeloma

S Mailankody, SM Devlin, J Landa… - New England journal …, 2022 - Mass Medical Soc
Background B-cell maturation antigen (BCMA)–directed chimeric antigen receptor (CAR) T-
cell therapies have generated responses in patients with advanced myeloma, but relapses …

Clinical activity of BMS-986393 (CC-95266), a G protein-coupled receptor class C group 5 member D (GPRC5D)-targeted chimeric antigen receptor (CAR) T cell …

S Bal, MH Kocoglu, O Nadeem, M Htut, T Gregory… - Blood, 2022 - ashpublications.org
Introduction: CAR T cell therapies targeting B-cell maturation antigen (BCMA) have resulted
in unprecedented depth and duration of response in R/R MM. However, relapses are …

GPRC5D CAR T cells (OriCAR-017) in patients with relapsed or refractory multiple myeloma (POLARIS): a first-in-human, single-centre, single-arm, phase 1 trial

M Zhang, G Wei, L Zhou, J Zhou, S Chen… - The Lancet …, 2023 - thelancet.com
Background Chimeric antigen receptor (CAR) T-cell therapy targeting B-cell maturation
antigen (BCMA) has shown activity in treating relapsed or refractory multiple myeloma; …

GPRC5D is a target for the immunotherapy of multiple myeloma with rationally designed CAR T cells

EL Smith, K Harrington, M Staehr… - Science translational …, 2019 - science.org
Early clinical results of chimeric antigen receptor (CAR) T cell therapy targeting B cell
maturation antigen (BCMA) for multiple myeloma (MM) appear promising, but relapses …

Anti–G Protein–Coupled Receptor, Class C Group 5 Member D Chimeric Antigen Receptor T Cells in Patients With Relapsed or Refractory Multiple Myeloma: A Single …

J Xia, H Li, Z Yan, D Zhou, Y Wang, Y Qi… - Journal of Clinical …, 2023 - ascopubs.org
PURPOSE G protein–coupled receptor, class C group 5 member D (GPRC5D) is considered
to be a promising surface target for multiple myeloma (MM) immunotherapy. Here, we report …

Bispecific BCMA/CD24 CAR-T cells control multiple myeloma growth

F Sun, Y Cheng, V Wanchai, W Guo, D Mery… - Nature …, 2024 - nature.com
Anti-multiple myeloma B cell maturation antigen (BCMA)-specific chimeric antigen receptor
(CAR) T-cell therapies represent a promising treatment strategy with high response rates in …

A phase 1 study of a novel fully human BCMA-targeting CAR (CT103A) in patients with relapsed/refractory multiple myeloma

D Wang, J Wang, G Hu, W Wang, Y Xiao… - Blood, The Journal …, 2021 - ashpublications.org
B-cell maturation antigen (BCMA)-specific chimeric antigen receptor (CAR) T-cell therapies
have shown efficacy in relapsed/refractory multiple myeloma (RRMM). Because the non …

Defining an optimal dual-targeted CAR T-cell therapy approach simultaneously targeting BCMA and GPRC5D to prevent BCMA escape–driven relapse in multiple …

C Fernández de Larrea, M Staehr, AV Lopez, KY Ng… - Blood cancer …, 2020 - AACR
Chimeric antigen receptor (CAR) T-cell therapy for multiple myeloma targeting B-cell
maturation antigen (TNFRSF17; BCMA) induces high overall response rates; however …

[HTML][HTML] Phase 1 study of C-CAR088, a novel humanized anti-BCMA CAR T-cell therapy in relapsed/refractory multiple myeloma

X Qu, G An, W Sui, T Wang, X Zhang… - … for immunotherapy of …, 2022 - ncbi.nlm.nih.gov
Background Anti-B-cell maturation antigen (BCMA) chimeric antigen receptor T-cell (CAR T)
therapy showed remarkable efficacy in patients with relapsed or refractory multiple myeloma …

Mechanisms of antigen escape from BCMA-or GPRC5D-targeted immunotherapies in multiple myeloma

H Lee, S Ahn, R Maity, N Leblay, B Ziccheddu… - Nature medicine, 2023 - nature.com
B cell maturation antigen (BCMA) target loss is considered to be a rare event that mediates
multiple myeloma (MM) resistance to anti-BCMA chimeric antigen receptor T cell (CAR T) or …