Organismal ageing is accompanied by progressive loss of cellular function and systemic
deterioration of multiple tissues, leading to impaired function and increased vulnerability to …

A hallmark of ageing is dysfunction in nutrient signalling pathways that regulate glucose
homeostasis, negatively affecting whole-body energy metabolism and ultimately increasing …

Genetic and pharmacological intervention studies have identified evolutionarily conserved
and functionally interconnected networks of cellular energy homeostasis, nutrient-sensing …

Aging is a natural biological process in living organisms characterized by receding
bioenergetics. Mitochondria are crucial for cellular bioenergetics and thus an important …

Mitochondria are key in the metabolism of aerobic organisms and in ageing progression and
age-related diseases. Mitochondria are essential for obtaining ATP from glucose and fatty …

Aging is a natural phenomenon characterized by progressive decline in tissue and organ
function leading to increased risk of disease and mortality. Among diverse factors that …

Mitochondrial dysfunction entailing decreased energy‐transducing capacity and perturbed
redox homeostasis is an early and sometimes initiating event in ageing and age‐related …

Aging is accompanied by a time-dependent progressive deterioration of multiple factors of
the cellular system. The past several decades have witnessed major leaps in our …

Mitochondria were described as early as 1890 as ubiquitous intracellular structures by
Ernster and Schatz (1981)[1]. Since then, the accretion of knowledge in the past century has …

Mitochondria are eukaryotic organelles known best for their roles in energy production and
metabolism. While often thought of as simply the 'powerhouse of the cell,'these organelles …