Alzheimer's disease is a genetically complex disorder; rare variants in the triggering receptor
expressed on myeloid cells 2 (TREM2) gene have been shown to as much as triple an …

Neurodegenerative disorders, including Alzheimer's disease, are associated with
microgliosis. Microglia have long been considered to have detrimental roles in Alzheimer's …

To the Editor: Guerreiro et al. 1 and Jonsson et al. 2 (Jan. 10 issue) report an association
between the single-nucleotide polymorphism (SNP) rs75932628 in the gene encoding the …

Guerreiro et al. 1 and Jonsson et al. 2 (Jan. 10 issue) report an association between the
singlenucleotide polymorphism (SNP) rs75932628 in the gene encoding the triggering …

Guerreiro et al. 1 and Jonsson et al. 2 (Jan. 10 issue) report an association between the
singlenucleotide polymorphism (SNP) rs75932628 in the gene encoding the triggering …

TREM2 (triggering receptor expressed on myeloid cells 2) gene variants were reported to
increase the risk of Alzheimer's disease (AD) and even other neurodegenerative diseases …

Background Homozygous loss-of-function mutations in TREM2, encoding the triggering
receptor expressed on myeloid cells 2 protein, have previously been associated with an …

Background Sequence variants, including the ε4 allele of apolipoprotein E, have been
associated with the risk of the common late-onset form of Alzheimer's disease. Few rare …

Homozygous mutations in exon 2 of TREM2, a gene involved in Nasu-Hakola disease, can
cause frontotemporal dementia (FTD). Moreover, a rare TREM2 exon 2 variant (p. R47H) …

Background A rare variant in the Triggering Receptor Expressed on Myeloid cells 2
(TREM2) gene has been reported to be a genetic risk factor for Alzheimer's disease by two …