Human preimplantation development involves extensive remodeling of RNA expression and
splicing. However, its transcriptome has been compiled using short-read sequencing data …

Our understanding of human pre-implantation development is limited by the availability of
human embryos and cannot completely rely on mouse studies. Petropoulos et al. now …

With readily available transcriptome-wide data, understanding the role of each expressed
gene is an essential next step. Although RNAi technologies allow for genome-wide screens …

The transcriptome of the preimplantation mouse embryo has been previously annotated by
short-read sequencing, with limited coverage and accuracy. Here we utilize a low-cell …

Successful human development is dependent upon a cascade of events following
fertilization. Unfortunately, knowledge of these critical events in humans is remarkably …

Early mammalian embryonic transcriptomes are dynamic throughout the process of
preimplantation development. Cataloging of primate transcriptomics during early …

Mammalian pre-implantation development is a complex process involving dramatic changes
in the transcriptional architecture,,,. We report here a comprehensive analysis of …

Pre-implantation embryo development is an intricate and precisely regulated process
orchestrated by maternally inherited proteins and newly synthesized proteins following …

Background During mammalian pre-implantation embryonic development dramatic and
orchestrated changes occur in gene transcription. The identification of the complete changes …

Early mouse embryos have an atypical translational machinery that consists of cytoplasmic
lattices and is poorly competent for translation. Hence, the impact of transcriptomic changes …