[HTML][HTML] Experimental treatment with favipiravir for Ebola virus disease (the JIKI Trial): a historically controlled, single-arm proof-of-concept trial in Guinea
D Sissoko, C Laouenan, E Folkesson… - PLoS …, 2016 - journals.plos.org
Background Ebola virus disease (EVD) is a highly lethal condition for which no specific
treatment has proven efficacy. In September 2014, while the Ebola outbreak was at its peak …
treatment has proven efficacy. In September 2014, while the Ebola outbreak was at its peak …
Laboratory findings, compassionate use of favipiravir, and outcome in patients with Ebola virus disease, Guinea, 2015—a retrospective observational study
R Kerber, E Lorenz, S Duraffour… - The Journal of …, 2019 - academic.oup.com
Background In 2015, the laboratory at the Ebola treatment center in Coyah, Guinea,
confirmed Ebola virus disease (EVD) in 286 patients. The cycle threshold (Ct) of an Ebola …
confirmed Ebola virus disease (EVD) in 286 patients. The cycle threshold (Ct) of an Ebola …
[HTML][HTML] Antiviral efficacy of favipiravir against Ebola virus: A translational study in cynomolgus macaques
J Guedj, G Piorkowski, F Jacquot, V Madelain… - PLoS …, 2018 - journals.plos.org
Background Despite repeated outbreaks, in particular the devastating 2014–2016 epidemic,
there is no effective treatment validated for patients with Ebola virus disease (EVD). Among …
there is no effective treatment validated for patients with Ebola virus disease (EVD). Among …
Clinical and virological characteristics of Ebola virus disease patients treated with favipiravir (T-705)—Sierra Leone, 2014
CQ Bai, JS Mu, D Kargbo, YB Song… - Clinical Infectious …, 2016 - academic.oup.com
Abstract Background. During 2014–2015, an outbreak of Ebola virus disease (EVD) swept
across parts of West Africa. No approved antiviral drugs are available for Ebola treatment …
across parts of West Africa. No approved antiviral drugs are available for Ebola treatment …
[HTML][HTML] Experimental treatment of Ebola virus disease with brincidofovir
J Dunning, SB Kennedy, A Antierens, J Whitehead… - PloS one, 2016 - journals.plos.org
Background The nucleotide analogue brincidofovir was developed to prevent and treat
infections caused by double-stranded DNA viruses. Based on in vitro data suggesting an …
infections caused by double-stranded DNA viruses. Based on in vitro data suggesting an …
[HTML][HTML] Favipiravir pharmacokinetics in Ebola-Infected patients of the JIKI trial reveals concentrations lower than targeted
THT Nguyen, J Guedj, X Anglaret… - PLoS neglected …, 2017 - journals.plos.org
Background In 2014–2015, we assessed favipiravir tolerance and efficacy in patients with
Ebola virus (EBOV) disease (EVD) in Guinea (JIKI trial). Because the drug had never been …
Ebola virus (EBOV) disease (EVD) in Guinea (JIKI trial). Because the drug had never been …
Treatment of Ebola virus disease
In March 2014, the largest Ebola outbreak in history exploded across West Africa. As of
November 14, 2014, the World Health Organization has reported a total of 21,296 Ebola …
November 14, 2014, the World Health Organization has reported a total of 21,296 Ebola …
[HTML][HTML] Experimental treatment of Ebola virus disease with TKM-130803: a single-arm phase 2 clinical trial
Background TKM-130803, a small interfering RNA lipid nanoparticle product, has been
developed for the treatment of Ebola virus disease (EVD), but its efficacy and safety in …
developed for the treatment of Ebola virus disease (EVD), but its efficacy and safety in …
[HTML][HTML] A randomized, controlled trial of Ebola virus disease therapeutics
S Mulangu, LE Dodd, RT Davey Jr… - New England journal …, 2019 - Mass Medical Soc
Background Although several experimental therapeutics for Ebola virus disease (EVD) have
been developed, the safety and efficacy of the most promising therapies need to be …
been developed, the safety and efficacy of the most promising therapies need to be …
[HTML][HTML] A systematic review of Ebola virus disease outbreaks and an analysis of the efficacy and safety of newer drugs approved for the treatment of Ebola virus …
P Sivanandy, PH Jun, LW Man, NS Wei… - Journal of Infection and …, 2022 - Elsevier
Abstract Background The Ebola virus has started to infect humans from time to time since
then and has led to several outbreaks. Due to urbanisation growth, invasion of forested …
then and has led to several outbreaks. Due to urbanisation growth, invasion of forested …