Metabolic rewiring and epigenetic remodeling, which are closely linked and reciprocally
regulate each other, are among the well-known cancer hallmarks. Recent evidence …

Metabolic reprogramming and epigenetic modifications are hallmarks of cancer cells. In
cancer cells, metabolic pathway activity varies during tumorigenesis and cancer …

Alterations in the epigenome and metabolism both affect molecular rewiring in cancer cells
and facilitate cancer development and progression. However, recent evidence suggests the …

Alterations in the epigenome and metabolism affect molecular rewiring of cancer cells
facilitating cancer development and progression. Modulation of histone and DNA …

Epigenetic alterations contribute to tumor development, progression, and therapeutic
response. Many epigenetic enzymes use metabolic intermediates as cofactors to modify …

Metabolic and epigenetic reprogramming are characteristics of cancer cells that, in many
cases, are linked. Oncogenic signaling, diet, and tumor microenvironment each influence …

Adaptation of cellular function with the nutrient environment is essential for survival. Failure
to adapt can lead to cell death and/or disease. Indeed, energy metabolism alterations are a …

Reversible, spatial, and temporal regulation of metabolic reprogramming and epigenetic
homeostasis are prominent hallmarks of carcinogenesis. Cancer cells reprogram their …

Epigenetic modifications and metabolism are two fundamental biological processes. During
tumorigenesis and cancer development both epigenetic and metabolic alterations occur and …

DNA methylation plays an important role in the silence of tissue-specific genes to prevent
them from being expressed in the wrong tissue. Aberrant DNA methylation (genome-wide …