[HTML][HTML] Histologic remission: the ultimate therapeutic goal in ulcerative colitis?

L Peyrin–Biroulet, A Bressenot, W Kampman - Clinical Gastroenterology …, 2014 - Elsevier
Ulcerative colitis (UC) is a disease of the mucosal layer, and activity of the disease is
assumed to be related to mucosal appearance. Mucosal healing has emerged as a major …

Histological remission in ulcerative colitis: under the microscope is the cure

T Chateau, R Feakins… - Official journal of the …, 2020 - journals.lww.com
In recent years, the therapeutic goals in ulcerative colitis (UC) have become increasingly
stringent. Histological features seem to be a reliable predictor of disease outcomes after …

Is histological healing a feasible endpoint in ulcerative colitis?

T Rath, R Atreya, MF Neurath - Expert Review of Gastroenterology …, 2021 - Taylor & Francis
Introduction Currently, treatment goals in ulcerative colitis aim to achieve clinical remission
and endoscopic mucosal healing. Emerging evidence suggests that histologic assessment …

defining remission in ulcerative colitis

SPL Travis, PDR Higgins, T Orchard… - Alimentary …, 2011 - Wiley Online Library
Aliment Pharmacol Ther 2011; 34: 113–124 Summary Background There is no international
agreement on scoring systems used to measure disease activity in ulcerative colitis, nor is …

the histological assessment of disease activity in ulcerative colitis

A Marchal Bressenot, RH Riddell… - Alimentary …, 2015 - Wiley Online Library
Backgound In patients with ulcerative colitis (UC), mucosal healing has emerged as a major
therapeutic goal, and is usually assessed endoscopically. Histological healing does not …

Histologic normalization occurs in ulcerative colitis and is associated with improved clinical outcomes

B Christensen, SB Hanauer, J Erlich, O Kassim… - Clinical …, 2017 - Elsevier
Background & Aims Mucosal healing, determined by histologic analysis, is a potential
therapeutic target for patients with ulcerative colitis (UC). However, the histologic features of …

Clinical study of the relation between mucosal healing and long‐term outcomes in ulcerative colitis

K Yokoyama, K Kobayashi, M Mukae… - Gastroenterology …, 2013 - Wiley Online Library
Background and Objectives. Mucosal healing (MH) is considered an important therapeutic
goal in ulcerative colitis (UC). We evaluate the severity of intestinal inflammation and clarify …

Histological disease activity as a predictor of clinical relapse among patients with ulcerative colitis: systematic review and meta-analysis

S Park, T Abdi, M Gentry, L Laine - Official journal of the American …, 2016 - journals.lww.com
Objectives: Endoscopic remission in ulcerative colitis (UC) is associated with improved
clinical outcomes. We assessed whether histological remission predicts clinical outcomes …

Histologic healing rates of medical therapies for ulcerative colitis: a systematic review and meta-analysis of randomized controlled trials

R Battat, M Duijvestein, L Guizzetti… - Official journal of the …, 2019 - journals.lww.com
OBJECTIVES: Histologic remission is a potentially valuable means of assessing disease
activity and treatment response in ulcerative colitis (UC). However, the efficacy of existing …

Importance of mucosal healing in ulcerative colitis

GR Lichtenstein, P Rutgeerts - Inflammatory bowel diseases, 2010 - academic.oup.com
Abstract Treatment of patients with ulcerative colitis (UC) has traditionally focused on
improving symptoms, with the main objective of inducing and maintaining symptomatic …