Allicin improves endoplasmic reticulum stress-related cognitive deficits via PERK/Nrf2 antioxidative signaling pathway

YF Zhu, XH Li, ZP Yuan, CY Li, RB Tian, W Jia… - European journal of …, 2015 - Elsevier
Endoplasmic reticulum (ER) stress is involved in neurodegenerative diseases including
Alzheimer's disease (AD), in which dysregulation of double-stranded RNA-dependent …

Allicin ameliorates cognitive deficits ageing-induced learning and memory deficits through enhancing of Nrf2 antioxidant signaling pathways

XH Li, CY Li, JM Lu, RB Tian, J Wei - Neuroscience letters, 2012 - Elsevier
Numerous studies have demonstrated that learning and memory abilities in the course of
normal aging cognitive abilities tend to decline and Nrf2 expression appears to decline with …

Naringenin attenuates endoplasmic reticulum stress, reduces apoptosis, and improves functional recovery in experimental traumatic brain injury

C Deng, R Yi, M Fei, T Li, Y Han, H Wang - Brain Research, 2021 - Elsevier
Traumatic brain injury (TBI) is a significant cause of disability and death worldwide.
Accumulating evidence suggests that endoplasmic reticulum (ER) stress would be an …

Allicin ameliorates cognitive impairment in APP/PS1 mice via suppressing oxidative stress by blocking JNK signaling pathways

H Zhang, P Wang, Y Xue, L Liu, Z Li, Y Liu - Tissue and Cell, 2018 - Elsevier
In middle and old age, Alzheimer's disease (AD) is a progressive neurodegenerative
disorder of brain. As an increasingly aging population, AD represents a huge burden for the …

Allicin attenuated chronic social defeat stress induced depressive-like behaviors through suppression of NLRP3 inflammasome

W Gao, W Wang, G Liu, J Zhang, J Yang… - Metabolic brain disease, 2019 - Springer
Allicin, one of the main biologically active compounds derived from garlic, was previously
reported to possess multiple pharmacological activities. Whether allicin protected against …

Neuroprotective effect of allicin against traumatic brain injury via Akt/endothelial nitric oxide synthase pathway-mediated anti-inflammatory and anti-oxidative activities

W Chen, J Qi, F Feng, G Bao, T Wang, M Xiang… - Neurochemistry …, 2014 - Elsevier
Allicin, one of the main biologically active compounds derived from garlic, has been shown
to exert various anti-oxidative and anti-inflammatory activities in in vitro and in vivo studies …

Phytochemical based Modulation of Endoplasmic Reticulum Stress in Alzheimer's Disease

VL Dsouza, AB Shivakumar, N Kulal… - Current Topics in …, 2022 - ingentaconnect.com
Alzheimer's disease (AD) is a severe progressive neurodegenerative condition that shows
misfolding and aggregation of proteins contributing to a decline in cognitive function …

Allicin ameliorates obesity comorbid depressive-like behaviors: involvement of the oxidative stress, mitochondrial function, autophagy, insulin resistance and NOX …

W Gao, W Wang, J Zhang, P Deng, J Hu, J Yang… - Metabolic brain …, 2019 - Springer
The increased prevalence of obesity has been a major medical and public health problem in
the past decades. In obese status, insulin resistance and sustained oxidative stress damage …

[HTML][HTML] Neuroprotective effect of naringin against cerebellar changes in Alzheimer's disease through modulation of autophagy, oxidative stress and tau expression …

HM Hassan, MR Elnagar, E Abdelrazik… - Frontiers in …, 2022 - frontiersin.org
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by gradual
cognitive decline. Strong antioxidants that inhibit free radicals, such as polyphenols, reduce …

[HTML][HTML] Berberine Reduces Aβ42 Deposition and Tau Hyperphosphorylation via Ameliorating Endoplasmic Reticulum Stress

Y Wu, Q Chen, B Wen, N Wu, B He… - Frontiers in …, 2021 - frontiersin.org
Alzheimer's disease (AD) is tightly related to endoplasmic reticulum stress (ER stress), which
aggravates two dominant pathological manifestations of AD: senile plaques and …